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- W3148954503 abstract "Scribe Therapeutics , a University of California, Berkeley, spin-off dedicated to designing new-and-improved CRISPR gene-editing systems, has raised $100 million in series B financing. Cofounder and CEO Benjamin Oakes says the money will help Scribe expand its 30-person team, build up its enzyme engineering platform, and accelerate development of gene-editing therapies for neurodegenerative diseases. As a PhD student in Jennifer Doudna’s and David Savage’s labs at Berkeley, Oakes designed new versions of Cas9, the DNA-cutting enzyme used in first-generation CRISPR gene editing. He created a version of Cas9 whose DNA cutting is allosterically controlled by small-molecule binding. And he used a protein-engineering trick called circular permutation to create a version of Cas9 whose DNA-cutting ability is kept inactive until protease enzymes cleave a chemical lock that lets Cas9 begin cutting. Doudna, Savage, Oakes, and Brett Stahl, a postdoc in Doudna’s lab, founded Scribe in 2018 to apply similar protein-engineering techniques" @default.
- W3148954503 created "2021-04-13" @default.
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- W3148954503 date "2021-04-05" @default.
- W3148954503 modified "2023-09-27" @default.
- W3148954503 title "CRISPR start-up Scribe raises $100 million" @default.
- W3148954503 doi "https://doi.org/10.1021/cen-09912-buscon4" @default.
- W3148954503 hasPublicationYear "2021" @default.
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