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• W3148959311 endingPage "102285" @default.
• W3148959311 startingPage "102285" @default.
• W3148959311 abstract "Disruption of the reparative process, often found in diabetic patients, results in chronic, non-healing wounds that significantly impact a patient's quality of life. This highlights the need of new therapeutic options to improve the healing of diabetic wounds. In this study, we focused on developing a cell-free hydrogel dressing loaded with mesenchymal stem cell (MSC)-conditioned media (CM) to potentially improve the healing of hard-to-heal wounds. We simulated a hyperglycemic environment by incubating human dermal fibroblasts in a high glucose environment (30 mM) and validated that MSC-CM rescued the impaired functions (proliferation and migration) of hyperglycemic fibroblasts. Further, we investigated the effect of loading MSC-CM in gelatin methacrylate (GelMA)-poly (ethylene glycol) diacrylate (PEGDA) hybrid hydrogels in improving the proliferative activity of glucose-treated fibroblasts. The controlled release of bioactive factors from MSC-CM loaded GelMA-PEGDA hydrogels promoted the metabolic activity of hyperglycemic fibroblasts. In addition, the growth rate of hyperglycemic fibroblasts was found to be similar to that of normal fibroblasts. Our observations, thus, suggest the potential application of cell-free, MSC-secretome-loaded hydrogel in the healing of diabetic or chronic wounds." @default.
• W3148959311 created "2021-04-13" @default.
• W3148959311 creator A5020675420 @default.
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• W3148959311 date "2021-06-01" @default.
• W3148959311 modified "2023-10-12" @default.
• W3148959311 title "Impact of mesenchymal stem cell-secretome-loaded hydrogel on proliferative and migratory activities of hyperglycemic fibroblasts" @default.
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• W3148959311 doi "https://doi.org/10.1016/j.mtcomm.2021.102285" @default.
• W3148959311 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8087264" @default.
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• W3148959311 hasPublicationYear "2021" @default.
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