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- W3149031323 abstract "淀粉贝它的(A) 的毒性强烈与 Alzheimers 疾病(广告) 被联系，它有高发生在老世界范围。最近的证据证明在 N-methyl-D-aspartate 受体(NMDAR ) 的活动的那改变在导致 A 的 neurotoxicity 起一个关键作用。然而， synaptic 的激活和 extrasynaptic NMDAR 为粘性，基因规定， neuronal 死亡，和生产有不同后果。这评论集中于 A 导致的 synaptic 和 extrasynaptic NMDAR 的 dysregulation。一方面， downregulates 由支持 NMDAR endocytosis 的 synaptic NMDAR 反应，导致 neurotoxicity 或 neuroprotection。在另一方面， A 由减少的 neuronal glutamate 举起和导致的 glutamate 溢出提高 extrasynaptic NMDAR 的激活，随后引起 neurotoxicity。另外，由 NMDA 的低剂量的 synaptic 活动的选择改进，或由 memantine 的 extrasynaptic 活动的减小，一个非竞争的 NMDAR 对手，停止导致 A 的 neurotoxicity。因此，为广告的未来 neuroprotective 药应该在两个瞄准 synaptic 活动和 extrasynaptic 的混乱的改进 NMDAR 依赖的死亡发信号。" @default.
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- W3149031323 date "2013-01-01" @default.
- W3149031323 modified "2023-09-24" @default.
- W3149031323 title "Dysregulation of synaptic and extrasynaptic N-methyl-D-aspartate receptors induced by amyloid-β" @default.
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