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- W3149031653 abstract "尽管表明小径的原子 factor-kappaB (NF-B ) 的组成的激活在多重不同人的肿瘤被报导了，在食道的有鳞的房间癌(ESCC ) 的 NF-B 小径的角色留下不清楚。丰富的来源提供了有趣的卓见进化疗和 chemopreventive 在癌症上完成的 curcumin 可以由调停的多重机制。在这研究，我们首先在二 ESCC 房间线 Eca109 和 EC9706 分析了 NF-B 小径的地位，然后进一步调查了 curcumin 是否能独自或在有 5 氟尿嘧啶(5-FU ) 的联合在 vitro 并且在 vivo 调制 NF-B 小径。结果证明 NF-B 发信号小径组成地在 ESCC 房间线被激活。Curcumin 经由 IB phosphorylation，和 downregulated 的抑制压制了 NF-B 的激活在 ESCC 房间线的 Bcl-2 和 CyclinD1 的表情。与 5-FU 相结合的 Curcumin 比独自对待的 5-FU 导致了更低的房间生存能力和更高的 apoptosis。在一个人的 ESCC 异种皮移植模型， curcumin 或 5-FU 独自减少了肿瘤体积，但是他们的联合有最强壮的 anticancer 效果。而且， curcumin 能也禁止在 vivo 通过 IB phosphorylation 和房间 apoptosis 的正式就职的 downregulation 表明小径的 NF-B。总的来说，我们的结果显示组成地激活的 NF-B 发信号小径在二个 ESCC 房间存在， curcumin 的 chemopreventive 效果与表明小径和它的下游的基因的 NF-B 的 downregulation 被联系。" @default.
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- W3149031653 date "2012-01-01" @default.
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- W3149031653 title "Curcumin potentiates the antitumor effects of 5-FU in treatment of esophageal squamous carcinoma cells through downregulating the activation of NF-κB signaling pathway in vitro and in vivo" @default.
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