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- W3149079420 abstract "瞄准：为了调查分子的小径，由基因表示介绍在人的 cholangiocarcinogenesis 包含了。方法：Oligonucleotide 数组(Affymetrix U133A ) 被用来与相应的非恶意的肝织物相比建立肝内 CCC 的特定的基因表达式侧面。在表示基因上验证大多数的表示价值， RT-PCR 实验被执行。结果：552 统计上，差别表示了 genes/ESTs (221 根探针显著地起来调整， 331 根探针下面调整；P 2；>=70%) 被识别。用这些数据和二维的簇分析，特定的基因表达式侧面被获得允许 CCC 的快、可再现的区别，它被监督神经元网络建模证实。大多数一致地在表示基因上(中部的褶层变化 33.5，显著地在上在 100% 表示了) 编码 osteopontin。而且，有组织病理学说的分级的各种各样的基因的一个协会能被表明。结论：为肝内 CCC 的高度特定的基因表示侧面被识别，允许它对非恶意的肝织物和另外的肝的快、可再现的歧视集中。在在肝内 CCC 的表示基因上的大多数是编码 osteopontin 的基因。这些数据可以导致人的 cholangiocarcinogenesis 的更好的理解。" @default.
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- W3149079420 date "2008-01-01" @default.
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- W3149079420 title "Identification of osteopontin as the most consistently over-expressed gene in intrahepatic cholangiocarcinoma： Detection by oligonucleotide microarray and real-time PCR analysis" @default.
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