Matches in SemOpenAlex for { <https://semopenalex.org/work/W3149087103> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W3149087103 endingPage "6" @default.
- W3149087103 startingPage "21" @default.
- W3149087103 abstract "Over the last decade, great progress has been made in elucidating how the human genome operates in the chromatin context. This paper describes our work on two human acetyltransferases, PCAF and TIP60, and their interaction partners. This study provides new clues on the function of these enzymes. In a striking parallel with the general transcription factor TFIID, PCAF complex contains proteins that have histone-like domains. We speculate that these subunits can presumably form a nucleosome-like structure on DNA, which would allow PCAF to contribute to the maintenance of an active state of chromatin. On the other hand, TIP60 complex contains two eukaryotic homologs of bacterial RuvB helicase/ATPse, involved in recombination and repair. Accordingly, expression of a dominant negative mutant of TIP60 in living cells interferes with their ability to repair DNA damage, which points out, for the first time, a role for a histone acetyltransferase in a process other than transcription. We also have evidence implicating TIP60 in the apoptotic response to DNA damage." @default.
- W3149087103 created "2021-04-13" @default.
- W3149087103 creator A5024618976 @default.
- W3149087103 date "2000-01-01" @default.
- W3149087103 modified "2023-09-23" @default.
- W3149087103 title "Mammalian histone acetyltransferase complexes." @default.
- W3149087103 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11188926" @default.
- W3149087103 hasPublicationYear "2000" @default.
- W3149087103 type Work @default.
- W3149087103 sameAs 3149087103 @default.
- W3149087103 citedByCount "0" @default.
- W3149087103 crossrefType "journal-article" @default.
- W3149087103 hasAuthorship W3149087103A5024618976 @default.
- W3149087103 hasConcept C10058791 @default.
- W3149087103 hasConcept C104317684 @default.
- W3149087103 hasConcept C107793267 @default.
- W3149087103 hasConcept C119157956 @default.
- W3149087103 hasConcept C2778001298 @default.
- W3149087103 hasConcept C2779649592 @default.
- W3149087103 hasConcept C2910921701 @default.
- W3149087103 hasConcept C54355233 @default.
- W3149087103 hasConcept C552990157 @default.
- W3149087103 hasConcept C56428682 @default.
- W3149087103 hasConcept C64927066 @default.
- W3149087103 hasConcept C83640560 @default.
- W3149087103 hasConcept C84772758 @default.
- W3149087103 hasConcept C86803240 @default.
- W3149087103 hasConcept C95444343 @default.
- W3149087103 hasConceptScore W3149087103C10058791 @default.
- W3149087103 hasConceptScore W3149087103C104317684 @default.
- W3149087103 hasConceptScore W3149087103C107793267 @default.
- W3149087103 hasConceptScore W3149087103C119157956 @default.
- W3149087103 hasConceptScore W3149087103C2778001298 @default.
- W3149087103 hasConceptScore W3149087103C2779649592 @default.
- W3149087103 hasConceptScore W3149087103C2910921701 @default.
- W3149087103 hasConceptScore W3149087103C54355233 @default.
- W3149087103 hasConceptScore W3149087103C552990157 @default.
- W3149087103 hasConceptScore W3149087103C56428682 @default.
- W3149087103 hasConceptScore W3149087103C64927066 @default.
- W3149087103 hasConceptScore W3149087103C83640560 @default.
- W3149087103 hasConceptScore W3149087103C84772758 @default.
- W3149087103 hasConceptScore W3149087103C86803240 @default.
- W3149087103 hasConceptScore W3149087103C95444343 @default.
- W3149087103 hasLocation W31490871031 @default.
- W3149087103 hasOpenAccess W3149087103 @default.
- W3149087103 hasPrimaryLocation W31490871031 @default.
- W3149087103 hasRelatedWork W1873722018 @default.
- W3149087103 hasRelatedWork W1994564112 @default.
- W3149087103 hasRelatedWork W1995910339 @default.
- W3149087103 hasRelatedWork W2026091658 @default.
- W3149087103 hasRelatedWork W2086507326 @default.
- W3149087103 hasRelatedWork W2108385007 @default.
- W3149087103 hasRelatedWork W2146724295 @default.
- W3149087103 hasRelatedWork W2523992079 @default.
- W3149087103 hasRelatedWork W3206112179 @default.
- W3149087103 hasRelatedWork W4224926712 @default.
- W3149087103 hasVolume "60 Suppl 2" @default.
- W3149087103 isParatext "false" @default.
- W3149087103 isRetracted "false" @default.
- W3149087103 magId "3149087103" @default.
- W3149087103 workType "article" @default.