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- W3149102318 abstract "Objective:To discuss the inhibitory action of pyrite and pyrola on bone metastasis in lung cancer.Methods: Take 15～20g nude mice,inject 0.1mL A549 cell suspension into marrow cavity of tibia of every nude mouse,after 14 days,establish the models of bone metastasis in lung cancer.Then they were randomLy divided into model control group,pyrite group,pyrola group and pamidronate group.Pyrola group and pamidronate group were separately administered the pyrite and pyrola with 6 g·kg-1 into stomach every other day.Pamidronate group were injected into enterocoelia with pamidronate disodium 10 mg·kg-1 every week.After three weeks,they were executed and weighed to measure the tumor volume and calculate the tumor-suppressing rate.Use the flow cytometer to detect apoptosis rate,blood biochemistry analyzer to calcium,phosphorus,alkaline phosphatase,hepatic/renal function and so on.Results:Compared to the model control group,the tumor volume has shrinked in each drug group.Pyrola group and pamidronate group apoptosis rate rised,and there were significant differences(P0.01).Calcium didn't differ significantly among each drug group;phosphorus rised in both pyrite and pyrola group;alkaline phosphatase declined in pamidronate group;there were statistical differences(P0.01,P0.05).AST went up remarkably in pyrite group(P0.05);in pamidronate group,AST and ALT both went up;the urea nitrogen and weight went down;differences were significant(P0.01).Compared to the pamidronate group,anti-tumor rate,phosphorus,alkaline phosphatase,weight and urea nitrogen all elevated in pyrite and pyrola group;ALT decreased.In pyrite group,apoptosis rate fell;in pyrola group,apoptosis rate and AST rised.All the differences were significant(P0.05,P0.01).Conclusion: Pyrite and pyrola both can control the growth of cancer cells in bone metastasis caused by lung cancer.One of the possible mechanism is to promote the tumor cell apoptosis with fewer side effects." @default.
- W3149102318 created "2021-04-13" @default.
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- W3149102318 date "2012-01-01" @default.
- W3149102318 modified "2023-09-23" @default.
- W3149102318 title "Inhibitory Action of Pyrite or Pyrola on Nude Mouse with Bone Metastasis in Lung Cancer" @default.
- W3149102318 hasPublicationYear "2012" @default.
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