Matches in SemOpenAlex for { <https://semopenalex.org/work/W3149129685> ?p ?o ?g. }
- W3149129685 endingPage "40" @default.
- W3149129685 startingPage "33" @default.
- W3149129685 abstract "Glucocorticoid-induced osteoporosis (GIOP) has emerged as a challenge after long-term glucocorticoid administration during the clinical therapy of diverse diseases. Although some candidates for GIOP treatment have been explored, there is still a lack of reliable drugs for GIOP prevention. In this study, rat bone marrow stem cells (rBMSCs) were utilized to investigate the feasibility of applying strontium gluconate (GluSr), which displays mild activity, easy absorption and good biocompatibility, for GIOP prevention. Thirty-two SD rats were divided into 4 groups to explore the effects of GluSr on osteoporosis rescue in vivo. Our results suggested that GluSr markedly alleviated dexamethasone (DEX)-induced apoptosis of osteoblast precursor cells and rBMSCs and enhanced rBMSC osteogenesis differentiation in vitro. GluSr also effectively promoted osteoblast survival, inhibited osteoclast differentiation and restored bone formation in GIOP rat models. Microarray analysis of the femora from GIOP rats treated with GluSr revealed that the signalling pathways of the glucocorticoid receptor (GR), oestrogen receptor gene (ESR) and vitamin D receptor (VDR) were involved in bone restoration by GluSr. In summary, our study proved that GluSr enhanced osteoblast differentiation and suppressed osteoclast activity both in vitro and in vivo. GluSr might function as a novel strontium reagent for GIOP prevention." @default.
- W3149129685 created "2021-04-13" @default.
- W3149129685 creator A5007072861 @default.
- W3149129685 creator A5021491996 @default.
- W3149129685 creator A5023930365 @default.
- W3149129685 creator A5027835055 @default.
- W3149129685 creator A5033472681 @default.
- W3149129685 creator A5040097650 @default.
- W3149129685 creator A5055725882 @default.
- W3149129685 creator A5070898395 @default.
- W3149129685 creator A5074820936 @default.
- W3149129685 date "2021-05-01" @default.
- W3149129685 modified "2023-10-17" @default.
- W3149129685 title "Strontium gluconate potently promotes osteoblast development and restores bone formation in glucocorticoid-induced osteoporosis rats" @default.
- W3149129685 cites W1945322507 @default.
- W3149129685 cites W1969402274 @default.
- W3149129685 cites W1994430971 @default.
- W3149129685 cites W1997812904 @default.
- W3149129685 cites W2038487059 @default.
- W3149129685 cites W2046335481 @default.
- W3149129685 cites W2056907680 @default.
- W3149129685 cites W2068356456 @default.
- W3149129685 cites W2076489036 @default.
- W3149129685 cites W2080443550 @default.
- W3149129685 cites W2080987932 @default.
- W3149129685 cites W2087853283 @default.
- W3149129685 cites W2092885411 @default.
- W3149129685 cites W2157956984 @default.
- W3149129685 cites W2160145148 @default.
- W3149129685 cites W2266782204 @default.
- W3149129685 cites W2769161407 @default.
- W3149129685 cites W2796114599 @default.
- W3149129685 cites W2942914003 @default.
- W3149129685 cites W2951846191 @default.
- W3149129685 cites W2953318722 @default.
- W3149129685 cites W3144695097 @default.
- W3149129685 doi "https://doi.org/10.1016/j.bbrc.2021.02.100" @default.
- W3149129685 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33774277" @default.
- W3149129685 hasPublicationYear "2021" @default.
- W3149129685 type Work @default.
- W3149129685 sameAs 3149129685 @default.
- W3149129685 citedByCount "4" @default.
- W3149129685 countsByYear W31491296852023 @default.
- W3149129685 crossrefType "journal-article" @default.
- W3149129685 hasAuthorship W3149129685A5007072861 @default.
- W3149129685 hasAuthorship W3149129685A5021491996 @default.
- W3149129685 hasAuthorship W3149129685A5023930365 @default.
- W3149129685 hasAuthorship W3149129685A5027835055 @default.
- W3149129685 hasAuthorship W3149129685A5033472681 @default.
- W3149129685 hasAuthorship W3149129685A5040097650 @default.
- W3149129685 hasAuthorship W3149129685A5055725882 @default.
- W3149129685 hasAuthorship W3149129685A5070898395 @default.
- W3149129685 hasAuthorship W3149129685A5074820936 @default.
- W3149129685 hasConcept C126322002 @default.
- W3149129685 hasConcept C134018914 @default.
- W3149129685 hasConcept C150903083 @default.
- W3149129685 hasConcept C170493617 @default.
- W3149129685 hasConcept C185592680 @default.
- W3149129685 hasConcept C202751555 @default.
- W3149129685 hasConcept C207001950 @default.
- W3149129685 hasConcept C2776033226 @default.
- W3149129685 hasConcept C2776541429 @default.
- W3149129685 hasConcept C2776594446 @default.
- W3149129685 hasConcept C2778260815 @default.
- W3149129685 hasConcept C2780841215 @default.
- W3149129685 hasConcept C55493867 @default.
- W3149129685 hasConcept C59493245 @default.
- W3149129685 hasConcept C673006 @default.
- W3149129685 hasConcept C71924100 @default.
- W3149129685 hasConcept C86803240 @default.
- W3149129685 hasConceptScore W3149129685C126322002 @default.
- W3149129685 hasConceptScore W3149129685C134018914 @default.
- W3149129685 hasConceptScore W3149129685C150903083 @default.
- W3149129685 hasConceptScore W3149129685C170493617 @default.
- W3149129685 hasConceptScore W3149129685C185592680 @default.
- W3149129685 hasConceptScore W3149129685C202751555 @default.
- W3149129685 hasConceptScore W3149129685C207001950 @default.
- W3149129685 hasConceptScore W3149129685C2776033226 @default.
- W3149129685 hasConceptScore W3149129685C2776541429 @default.
- W3149129685 hasConceptScore W3149129685C2776594446 @default.
- W3149129685 hasConceptScore W3149129685C2778260815 @default.
- W3149129685 hasConceptScore W3149129685C2780841215 @default.
- W3149129685 hasConceptScore W3149129685C55493867 @default.
- W3149129685 hasConceptScore W3149129685C59493245 @default.
- W3149129685 hasConceptScore W3149129685C673006 @default.
- W3149129685 hasConceptScore W3149129685C71924100 @default.
- W3149129685 hasConceptScore W3149129685C86803240 @default.
- W3149129685 hasFunder F4320326705 @default.
- W3149129685 hasFunder F4320336026 @default.
- W3149129685 hasLocation W31491296851 @default.
- W3149129685 hasOpenAccess W3149129685 @default.
- W3149129685 hasPrimaryLocation W31491296851 @default.
- W3149129685 hasRelatedWork W1975196675 @default.
- W3149129685 hasRelatedWork W2014748488 @default.
- W3149129685 hasRelatedWork W2016215251 @default.
- W3149129685 hasRelatedWork W2055040528 @default.
- W3149129685 hasRelatedWork W2183727096 @default.
- W3149129685 hasRelatedWork W2325218104 @default.