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- W3149134306 abstract "Creutzfeldt-Jakob disease (CJD) refers to the most common transmissible spongiform encephalopathies. The distinction between a diagnosis of sporadically acquired CJD and the exogenously acquired CJD is important, and has previously been assisted by imaging modalities revealing the pulvinar sign. This case report describes a 71-year-old native-American female with rapidly deteriorating mental status, progressive personality changes, ataxia, and 50-pound weight loss. Non-contrast MRI of the brain was significant for symmetrical high diffusion signal in the bilateral pulvinar thalami. CSF studies performed by the National Prion Disease Surveillance Center showed a positive 14-3-3 level and an elevated tau conveying a positive predictive value of 72.6% for CJD. The case exemplifies commonality between sporadic CJD and variant CJD and challenges the utility of radiological findings differentiating the diseases. Our case emphasizes that the pulvinar sign may not be as specific for a diagnosing variant CJD as we once thought. J Med Cases. 2013;4(11):765-768 doi: https://doi.org/10.4021/jmc1278w" @default.
- W3149134306 created "2021-04-13" @default.
- W3149134306 creator A5074761157 @default.
- W3149134306 date "2013-01-01" @default.
- W3149134306 modified "2023-09-30" @default.
- W3149134306 title "Pulvinar Sign in Sporadic Creutzfeldt-Jakob Disease: Exploring the Diagnostic Modalities of Prion Diseases" @default.
- W3149134306 doi "https://doi.org/10.4021/jmc1278w" @default.
- W3149134306 hasPublicationYear "2013" @default.
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