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- W3149154666 abstract "A LI M EN TA R Y TR A C T ACKGROUND & AIMS: The small bowel mucosa is ensitive to nutrients and undergoes rapid adaptation to utrient deprivation and refeeding through changes in poptosis and cell proliferation, respectively. Although lucagon-like peptide-2 (GLP-2) exerts trophic effects on he gut and levels increase with refeeding, mechanisms inking GLP-2 to mucosal adaptation to refeeding remain nclear. METHODS: Fasting and refeeding were studied n wild-type (WT) and Glp2r / mice and in WT mice reated with the pan ErbB inhibitor CI-1033. Experimenal end points included intestinal weights, histomorhometry, gene and protein expression, and crypt cell roliferation. RESULTS: Fasting was associated with sigificant reductions in small bowel mass, decreased crypt lus villus height, and reduced crypt cell proliferation. efeeding increased plasma levels of GLP-2, reversed mall bowel atrophy, increased villus height and cell umber, and stimulated jejunal crypt cell proliferation. n contrast, refeeding failed to increase small bowel eight, crypt cell proliferation, or villus cell number in lp2r / mice. Levels of mRNA transcripts for egf, kgf, nd igfr were lower in fasted Glp2r / mice. Epidermal rowth factor but not insulin-like growth factor-1 retored the intestinal adaptive response to refeeding in lp2r / mice. Furthermore, CI-1033 prevented adaptive rypt cell proliferation, Akt activation, and induction of rbB ligand gene expression after refeeding. Up-regulaion of ErbB ligand expression and intestinal Akt phoshorylation were significantly diminished in refed lp2r / mice. CONCLUSIONS: These findings idenify Glp2r and ErbB pathways as essential components f the signaling network regulating the adaptive muosal response to refeeding in the mouse intestine." @default.
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- W3149154666 date "2010-01-01" @default.
- W3149154666 modified "2023-09-27" @default.
- W3149154666 title "rbB Activity Links the Glucagon-Like Peptide-2 Receptor to efeeding-Induced Adaptation in the Murine Small Bowel" @default.
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