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- W3149156769 abstract "Objective and design Serine proteases and phorbol-12myristate-13-acetate (PMA) are able to induce the release of pro-inflammatory interleukin-6 (IL-6) in monocytic cells. The present study was performed to investigate whether there is any interaction between proteases and phorbol ester in IL-6 release. Methods U-937 cells differentiated with interferon-c were treated with or without thrombin, trypsin, papain (each 1‐10 lg/ml) and PMA (0.1‐10 ng/ml) or the combination of both enzyme and PMA for up to 72 h and the release of IL-6 was determined by enzyme-linked immunosorbent assay. Results Thrombin and PMA caused a time- and dosedependent increase in IL-6. The combination of the two resulted in an increase up to fivefold higher than each agent alone. Even the combination of the cysteine protease papain and PMA showed a strong effect on IL-6 release compared to the individual tests. Conclusions These findings suggest a synergistic activity between phorbol ester and proteases to promote inflammation." @default.
- W3149156769 created "2021-04-13" @default.
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- W3149156769 date "2012-01-01" @default.
- W3149156769 modified "2023-09-27" @default.
- W3149156769 title "Enhancement of protease-induced IL-6 release in monocytic U-937 cells by phorbol-12-myristate-13-acetate" @default.
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