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- W3149168465 abstract "Introduction: Nonrandomized retrospective studies have suggested that laparoscopic distal pancreatectomy (LDP) is advantageous compared to open (ODP) regarding hospital stay, blood loss and recovery. The only randomized study is available shows enhanced functional recovery after LDP. Methods: Sixty patients, evaluated at a multidisciplinary tumor board and planed for standard distal pancreatectomy were prospectively randomized to LDP or ODP in a parallel group, single-center superiority trial. The primary outcome was postoperative hospital stay with the hypothesis that LDP would shorten it. Results: Fifty-eight patients, 34 male and 24 female, were assigned to LDP (n=29, mean age 68 years) vs. to ODP (n=29, mean age 63 years) and included in a intention-to-treat analysis. The postoperative hospital stay was 5 (IQR 4-5) days in the LDP group vs. 6 (5-7) days in the ODP group (P=0.002). Functional recovery was reached after 4 (2-6) vs. 6 (4-7) days (P=0.007), and the operation time was 120 minutes in both groups (P=0.48). Blood loss was reduced with LDP, 50 (25-150) compared to 100 mL (100-300) (P=0.018). No difference was found in the complication rates with 4 vs. 8 patients in the LDP and ODP groups respectively experiencing complication of Clavien-Dindo grade 3 or higher. Similarly, the rate of post pancreatectomy fistula did not differ between the groups (9 vs. 11 patients). Conclusions: LDP is associated with shorter hospital stay, enhanced functional recovery and less bleeding as compared to ODP, and should therefore be considered the as the treatment standard for patients in need of distal pancreatectomy." @default.
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- W3149168465 date "2021-01-01" @default.
- W3149168465 modified "2023-09-26" @default.
- W3149168465 title "Laparoscopic Distal Pancreatectomy Shortens Hospital Stay: Results from a Single-Center, Randomized Controlled Trial (LAPOP)" @default.
- W3149168465 doi "https://doi.org/10.1016/j.hpb.2020.11.143" @default.
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