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- W3149191610 abstract "一个病毒提出的流行性感冒对全球健康的大威胁，和 oseltamivir (作为 Tamiflu 标记的贸易) ，指向流行性感冒表面 glycoprotein neuraminidase (NA ) ，临床上被用作一个主要反流行性感冒处理。然而，在 NA 的某些替换能使一个流行性感冒病毒变为抵抗到这药。在这研究，使用一个 lentiviral pseudotyping 系统，它减轻安全学习象鸟的流行性感冒 H5N1 那样的高度病原的流行性感冒病毒担心，那利用流行性感冒表面 glycoproteins (红血球凝聚素或哈，并且 NA )并且HIV核心作为代理人试金与酶记者基因结合了，我们首先由在 oseltamivir 的缺席或存在测量 pseudovirion 版本估计了 NA 的功能。我们证明 oseltamivir 在 NA 活动显示剂量依赖者抑制。相反，变异的 NA (H274Y ) 对 oseltamivir 处理更抵抗。另外，几以前报导的替换 NA 异种的效果也被检验。我们的结果证明这个基于 lentivirus 的 pseudotyping 系统提供一个快、安全、有效的方法估计抵抗到 neuraminidase 禁止者。并且当新变化出现在流行性感冒，我们相信那孤立，他们现在和将来的 anti-NA 的有效性上的影响能被这试金快速并且可靠地评估。" @default.
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- W3149191610 date "2013-01-01" @default.
- W3149191610 modified "2023-09-24" @default.
- W3149191610 title "Analysis of Oseltamivir Resistance Substitutions in Influenza Virus Glycoprotein Neuraminidase using a Lentivirus-Based Surrogate Assay System" @default.
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