FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3149192013> ?p ?o ?g. }

• W3149192013 endingPage "9448" @default.
• W3149192013 startingPage "9442" @default.
• W3149192013 abstract "The proinflammatory cytokine interleukin-1 β (IL-1β)-mediated cellular senescence in chondrocytes is involved in the development and pathological progression of osteoarthritis (OA). Feprazone, a nonsteroidal anti-inflammatory drug (NSAID) and a cyclooxygenase (COX) inhibitor, is widely used in clinics. This study aims to investigate whether Feprazone has a protective effect against IL-1β-induced cellular senescence in human chondrocytes. In this study, C-28/I2 chondrocytes were stimulated with IL-1β (10 ng/mL) in the presence or absence of Feprazone (10 and 20 μM). Cellular senescence was assessed using senescence-associated β-galactosidase (SA-β-Gal) staining. The cell cycle was examined using flow cytometry. Gene and protein expressions were determined with real-time polymerase chain reaction (PCR) and western blot analysis. We found that treatment with Feprazone ameliorated IL-1β-induced increase in cellular senescence. Feprazone increased telomerase activity and prevented cell cycle arrest in the G0/G1 phase. We also found that Feprazone reduced the expressions of plasminogen activator inhibitor-1 (PAI-1) and p21, two important regulators of cellular senescence. Additionally, treatment with Feprazone reduced the expressions of matrix metalloprotein (MMP-13) and a disintegrin-like and metalloproteinase with thrombospondin type-1 motif-5 (ADAMTS-5). Interestingly, Feprazone prevented the activation of nuclear factor kappa-B (NF-κB) by preventing nuclear translocation of NF-κB p65 and the luciferase activity of the NF-κB promoter. The results also show that Feprazone increased nuclear levels of nuclear factor erythroid 2-related factor-2 (Nrf2) and reduced the production of reactive oxygen species (ROS). Importantly, silencing of Nrf2 abolished the protective effects of Feprazone against IL-1β-induced NF-κB activation and cellular senescence. These findings shed light on the potential use of Feprazone in the treatment of OA based on a novel mechanism." @default.
• W3149192013 created "2021-04-13" @default.
• W3149192013 creator A5002593425 @default.
• W3149192013 creator A5041411176 @default.
• W3149192013 creator A5046664698 @default.
• W3149192013 date "2021-03-31" @default.
• W3149192013 modified "2023-10-02" @default.
• W3149192013 title "Feprazone Mitigates IL-1β-Induced Cellular Senescence in Chondrocytes" @default.
• W3149192013 cites W1982353151 @default.
• W3149192013 cites W198987307 @default.
• W3149192013 cites W1991758957 @default.
• W3149192013 cites W2025243746 @default.
• W3149192013 cites W2087751447 @default.
• W3149192013 cites W2087958138 @default.
• W3149192013 cites W2088162928 @default.
• W3149192013 cites W2117800935 @default.
• W3149192013 cites W2132826785 @default.
• W3149192013 cites W2133915381 @default.
• W3149192013 cites W2153079244 @default.
• W3149192013 cites W2164993228 @default.
• W3149192013 cites W2207241376 @default.
• W3149192013 cites W2327601668 @default.
• W3149192013 cites W2408037563 @default.
• W3149192013 cites W2546215880 @default.
• W3149192013 cites W2582214777 @default.
• W3149192013 cites W2735754703 @default.
• W3149192013 cites W2783179963 @default.
• W3149192013 cites W2794139372 @default.
• W3149192013 cites W2884254952 @default.
• W3149192013 cites W2886550702 @default.
• W3149192013 cites W2902542974 @default.
• W3149192013 cites W2910427173 @default.
• W3149192013 cites W2913341946 @default.
• W3149192013 cites W2941699855 @default.
• W3149192013 cites W2983403094 @default.
• W3149192013 cites W2996537794 @default.
• W3149192013 cites W4235790631 @default.
• W3149192013 cites W860291315 @default.
• W3149192013 doi "https://doi.org/10.1021/acsomega.0c06066" @default.
• W3149192013 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8047674" @default.
• W3149192013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33869924" @default.
• W3149192013 hasPublicationYear "2021" @default.
• W3149192013 type Work @default.
• W3149192013 sameAs 3149192013 @default.
• W3149192013 citedByCount "7" @default.
• W3149192013 countsByYear W31491920132022 @default.
• W3149192013 countsByYear W31491920132023 @default.
• W3149192013 crossrefType "journal-article" @default.
• W3149192013 hasAuthorship W3149192013A5002593425 @default.
• W3149192013 hasAuthorship W3149192013A5041411176 @default.
• W3149192013 hasAuthorship W3149192013A5046664698 @default.
• W3149192013 hasBestOaLocation W31491920133 @default.
• W3149192013 hasConcept C104317684 @default.
• W3149192013 hasConcept C1491633281 @default.
• W3149192013 hasConcept C153911025 @default.
• W3149192013 hasConcept C164027704 @default.
• W3149192013 hasConcept C185592680 @default.
• W3149192013 hasConcept C203014093 @default.
• W3149192013 hasConcept C2776415932 @default.
• W3149192013 hasConcept C2776914184 @default.
• W3149192013 hasConcept C29537977 @default.
• W3149192013 hasConcept C522857546 @default.
• W3149192013 hasConcept C55493867 @default.
• W3149192013 hasConcept C86803240 @default.
• W3149192013 hasConcept C95444343 @default.
• W3149192013 hasConceptScore W3149192013C104317684 @default.
• W3149192013 hasConceptScore W3149192013C1491633281 @default.
• W3149192013 hasConceptScore W3149192013C153911025 @default.
• W3149192013 hasConceptScore W3149192013C164027704 @default.
• W3149192013 hasConceptScore W3149192013C185592680 @default.
• W3149192013 hasConceptScore W3149192013C203014093 @default.
• W3149192013 hasConceptScore W3149192013C2776415932 @default.
• W3149192013 hasConceptScore W3149192013C2776914184 @default.
• W3149192013 hasConceptScore W3149192013C29537977 @default.
• W3149192013 hasConceptScore W3149192013C522857546 @default.
• W3149192013 hasConceptScore W3149192013C55493867 @default.
• W3149192013 hasConceptScore W3149192013C86803240 @default.
• W3149192013 hasConceptScore W3149192013C95444343 @default.
• W3149192013 hasIssue "14" @default.
• W3149192013 hasLocation W31491920131 @default.
• W3149192013 hasLocation W31491920132 @default.
• W3149192013 hasLocation W31491920133 @default.
• W3149192013 hasLocation W31491920134 @default.
• W3149192013 hasOpenAccess W3149192013 @default.
• W3149192013 hasPrimaryLocation W31491920131 @default.
• W3149192013 hasRelatedWork W1932046626 @default.
• W3149192013 hasRelatedWork W1980527388 @default.
• W3149192013 hasRelatedWork W2026930740 @default.
• W3149192013 hasRelatedWork W2027931017 @default.
• W3149192013 hasRelatedWork W2049235132 @default.
• W3149192013 hasRelatedWork W2064885484 @default.
• W3149192013 hasRelatedWork W2108273756 @default.
• W3149192013 hasRelatedWork W2117470261 @default.
• W3149192013 hasRelatedWork W2135804517 @default.
• W3149192013 hasRelatedWork W2289076774 @default.
• W3149192013 hasVolume "6" @default.
• W3149192013 isParatext "false" @default.
• W3149192013 isRetracted "false" @default.

• next