FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3149200123> ?p ?o ?g. }

• W3149200123 abstract "Hepatocellular carcinoma (HCC) is a malignant tumor of the digestive system characterized by mortality rate and poor prognosis. To indicate the prognosis of HCC patients, lots of genes have been screened as prognostic indicators. However, the predictive efficiency of single gene is not enough. Therefore, it is essential to identify a risk-score model based on gene signature to elevate predictive efficiency.Lasso regression analysis followed by univariate Cox regression was employed to establish a risk-score model for HCC prognosis prediction based on The Cancer Genome Atlas (TCGA) dataset and Gene Expression Omnibus (GEO) dataset GSE14520. R package 'clusterProfiler' was used to conduct function and pathway enrichment analysis. The infiltration level of various immune and stromal cells in the tumor microenvironment (TME) were evaluated by single-sample GSEA (ssGSEA) of R package 'GSVA'.This prognostic model is an independent prognostic factor for predicting the prognosis of HCC patients and can be more effective by combining with clinical data through the construction of nomogram model. Further analysis showed patients in high-risk group possess more complex TME and immune cell composition.Taken together, our research suggests the thirteen-gene signature to possess potential prognostic value for HCC patients and provide new information for immunological research and treatment in HCC." @default.
• W3149200123 created "2021-04-13" @default.
• W3149200123 creator A5002326754 @default.
• W3149200123 creator A5044442488 @default.
• W3149200123 creator A5063192831 @default.
• W3149200123 creator A5063481044 @default.
• W3149200123 creator A5072967834 @default.
• W3149200123 date "2021-04-01" @default.
• W3149200123 modified "2023-10-01" @default.
• W3149200123 title "Identification of a thirteen-gene signature predicting overall survival for hepatocellular carcinoma" @default.
• W3149200123 cites W1511587980 @default.
• W3149200123 cites W1988619719 @default.
• W3149200123 cites W2035618305 @default.
• W3149200123 cites W2041161084 @default.
• W3149200123 cites W2045030989 @default.
• W3149200123 cites W2071264409 @default.
• W3149200123 cites W2091415498 @default.
• W3149200123 cites W2151305493 @default.
• W3149200123 cites W2745944456 @default.
• W3149200123 cites W2767476911 @default.
• W3149200123 cites W2785803176 @default.
• W3149200123 cites W2790059016 @default.
• W3149200123 cites W2792825631 @default.
• W3149200123 cites W2802034549 @default.
• W3149200123 cites W2889646458 @default.
• W3149200123 cites W2893122725 @default.
• W3149200123 cites W2898661148 @default.
• W3149200123 cites W2901881861 @default.
• W3149200123 cites W2905562353 @default.
• W3149200123 cites W2920600229 @default.
• W3149200123 cites W2945880281 @default.
• W3149200123 cites W2948017644 @default.
• W3149200123 cites W2949179534 @default.
• W3149200123 cites W2949273159 @default.
• W3149200123 cites W2956024695 @default.
• W3149200123 cites W2959497269 @default.
• W3149200123 cites W2962449430 @default.
• W3149200123 cites W2997738117 @default.
• W3149200123 cites W3049726495 @default.
• W3149200123 cites W3083474699 @default.
• W3149200123 cites W3094820759 @default.
• W3149200123 cites W3128337926 @default.
• W3149200123 doi "https://doi.org/10.1042/bsr20202870" @default.
• W3149200123 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8065179" @default.
• W3149200123 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33835133" @default.
• W3149200123 hasPublicationYear "2021" @default.
• W3149200123 type Work @default.
• W3149200123 sameAs 3149200123 @default.
• W3149200123 citedByCount "3" @default.
• W3149200123 countsByYear W31492001232021 @default.
• W3149200123 countsByYear W31492001232022 @default.
• W3149200123 countsByYear W31492001232023 @default.
• W3149200123 crossrefType "journal-article" @default.
• W3149200123 hasAuthorship W3149200123A5002326754 @default.
• W3149200123 hasAuthorship W3149200123A5044442488 @default.
• W3149200123 hasAuthorship W3149200123A5063192831 @default.
• W3149200123 hasAuthorship W3149200123A5063481044 @default.
• W3149200123 hasAuthorship W3149200123A5072967834 @default.
• W3149200123 hasBestOaLocation W31492001231 @default.
• W3149200123 hasConcept C104317684 @default.
• W3149200123 hasConcept C11783203 @default.
• W3149200123 hasConcept C119857082 @default.
• W3149200123 hasConcept C126322002 @default.
• W3149200123 hasConcept C136764020 @default.
• W3149200123 hasConcept C143998085 @default.
• W3149200123 hasConcept C150194340 @default.
• W3149200123 hasConcept C161584116 @default.
• W3149200123 hasConcept C16930146 @default.
• W3149200123 hasConcept C199163554 @default.
• W3149200123 hasConcept C2778019345 @default.
• W3149200123 hasConcept C2779134260 @default.
• W3149200123 hasConcept C2779733811 @default.
• W3149200123 hasConcept C34626388 @default.
• W3149200123 hasConcept C37616216 @default.
• W3149200123 hasConcept C41008148 @default.
• W3149200123 hasConcept C50382708 @default.
• W3149200123 hasConcept C55493867 @default.
• W3149200123 hasConcept C71924100 @default.
• W3149200123 hasConcept C86803240 @default.
• W3149200123 hasConceptScore W3149200123C104317684 @default.
• W3149200123 hasConceptScore W3149200123C11783203 @default.
• W3149200123 hasConceptScore W3149200123C119857082 @default.
• W3149200123 hasConceptScore W3149200123C126322002 @default.
• W3149200123 hasConceptScore W3149200123C136764020 @default.
• W3149200123 hasConceptScore W3149200123C143998085 @default.
• W3149200123 hasConceptScore W3149200123C150194340 @default.
• W3149200123 hasConceptScore W3149200123C161584116 @default.
• W3149200123 hasConceptScore W3149200123C16930146 @default.
• W3149200123 hasConceptScore W3149200123C199163554 @default.
• W3149200123 hasConceptScore W3149200123C2778019345 @default.
• W3149200123 hasConceptScore W3149200123C2779134260 @default.
• W3149200123 hasConceptScore W3149200123C2779733811 @default.
• W3149200123 hasConceptScore W3149200123C34626388 @default.
• W3149200123 hasConceptScore W3149200123C37616216 @default.
• W3149200123 hasConceptScore W3149200123C41008148 @default.
• W3149200123 hasConceptScore W3149200123C50382708 @default.
• W3149200123 hasConceptScore W3149200123C55493867 @default.
• W3149200123 hasConceptScore W3149200123C71924100 @default.
• W3149200123 hasConceptScore W3149200123C86803240 @default.
• W3149200123 hasIssue "4" @default.

• next