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- W3149253419 abstract "Organophosphate pesticides exert their toxic effects by cholinesterase inhibition and the consequent proiongation of the undesirable effects of accumulation of acetylcholine. The signs of toxicity include tremors. convulsions. lachrymation. urination. defecation etc. However. prolonged cholinesterase inhibition through sustained administration of organophosphates could lead to the gradual disappearance of the in itial signs of toxicity in the course of time. termed behavioral tolerance. The present study was undertaken to examine in albino rats the development of behaviorai tolerance to phosalone. an organophosphate insecticide commonly used in agricultural operations. After determining the LDso dose, oral doses ranging between Yi LD 50 to Ys LD50 (both inciusive) were . administered dail y for a period of 15 days to six batches of rats (each batch of 12- 20 animals ), and changes in consummatory behavior (eating and drinking), body weight and cumulative mortality were monitored daily to assess the development of behavioral tolerance at a particular dose. The onset and disappearance and frequency of toxic signs and symptoms were also taken into consideration to arrive at a daily sublethal tolerable oral dose of phosalone. A dose of % LD50 was fi nally selected for daily dosing for 1 5 days. The occurrence of tremors and convulsions was observed each day after dosing during a time period of 6h at intervals of Yih. 2h , 3h , and 6h. The study revealed that albino rats develop behavioral tolerance to - phosalone toxicity. This may have implications in agricultural operations employing this insecticide." @default.
- W3149253419 created "2021-04-13" @default.
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- W3149253419 date "2007-01-01" @default.
- W3149253419 modified "2023-09-23" @default.
- W3149253419 title "ON THE DEVELOPMENT OF BEHAVIORAL TOLERANCE TO THE ORGANOPHOSPHATE INSECTICIDE PHOSALONE IN RATS" @default.
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