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- W3149255562 abstract "This paper depicted results of the investigation on the physiological disposition of ~3H-indirubin and its derivatives ~3H-79002 and 3H-79005 in mice and rats.All the examined compounds were found to be poorly absorbed from the gastrointestinal tract of mice, but 3H-79002 was absorbed more rapidly and moreCompletely than ~3H-indirubin, 3H-79005 was absorbed less rapidly and less completely.In tumor tissue of Lewis lung cancer, the radioactivity of ~3H-79002 was about twice as high as that of the other two compounds. Only in the gastrointestinal tract was the radioactivity of SH-79005 much higher than that of the other two com pounds at 12-hr after oral administration.Examination of the metabolites of these compounds by TLC revealed that there was very little radioactivity of unchanged compound in every group, most of the radioactivity appeared as various metabolites. According to the analysis of the urine in animals treated with 3H-79002 or aH-79005 by using TLC, about 1/3 of the total radioactivity on the chromatogram behaved as ~3H-indirubin.These results showed that the differences in physiological disposition of these three compounds might be one of the factors influencing their antitumor activity." @default.
- W3149255562 created "2021-04-13" @default.
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- W3149255562 date "1983-01-01" @default.
- W3149255562 modified "2023-09-25" @default.
- W3149255562 title "A COMPARATIVE STUDY ON THE PHYSIOLOGICAL DISPOSITION OF ~3H-INDIRUBIN AND ITS DERIVATIVES 3H-79002 AND ~3H-79005 IN ANIMALS" @default.
- W3149255562 hasPublicationYear "1983" @default.
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