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• W3149262018 abstract "Abstract Molecular methods detect genetic mutations associated with drug resistance. This study detected resistance-conferring mutations in gyrA / gyrB for fluoroquinolones and rrs / eis genes for second-line injectable drugs (SLIDs) among multidrug-resistant Mycobacterium tuberculosis (MDR-TB) isolates in Kuwait. Fifty pansusceptible M. tuberculosis and 102 MDR-TB strains were tested. Phenotypic susceptibility testing was performed by MGIT 960 system using SIRE drug kit. GenoType MTBDR sl version 1 (gMTBDR sl v1) and GenoType MTBDR sl version 2 (gMTBDR sl v2) tests were used for mutation detection. Results were validated by PCR-sequencing of respective genes. Fingerprinting was performed by spoligotyping. No mutations were detected in pansusceptible isolates. gMTBDR sl v1 detected gyrA mutations in 12 and rrs mutations in 8 MDR-TB isolates. gMTBDR sl 2 additionally detected gyrB mutations in 2 and eis mutation in 1 isolate. Mutations in both gyrA/gyrB and rrs/eis were not detected. gMTBDR sl v1 also detected ethambutol resistance-conferring embB mutations in 59 isolates. Although XDR-TB was not detected, frequency of resistance-conferring mutations for fluoroquinolones or SLIDs was significantly higher among isolates collected during 2013–2019 versus 2006–2012. Application of both tests is warranted for proper management of MDR-TB patients in Kuwait as gMTBDR sl v2 detected resistance to fluoroquinolones and/or SLIDs in 3 additional isolates while gMTBDR sl v1 additionally detected resistance to ethambutol in 58% of MDR-TB isolates." @default.
• W3149262018 created "2021-04-13" @default.
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• W3149262018 date "2021-04-08" @default.
• W3149262018 modified "2023-10-15" @default.
• W3149262018 title "Increasing prevalence of resistance to second-line drugs among multidrug-resistant Mycobacterium tuberculosis isolates in Kuwait" @default.
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• W3149262018 doi "https://doi.org/10.1038/s41598-021-87516-0" @default.
• W3149262018 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8032671" @default.
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• W3149262018 hasPublicationYear "2021" @default.
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