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• W3149263889 abstract "Voltage-gated potassium channels are regula- tors of membrane potentials, action potential shape, firing adaptation, and neuronal excitability in excitable tissues including in the primary sensory neurons of dorsal root ganglion (DRG). In this study, using the whole-cell patch- clamp technique, the effect of estradiol (E2) on voltage- gated total outward potassium currents, the component currents transient ''A-type'' current (IA) currents, and ''delayed rectifier type'' (IKDR) currents in isolated mouse DRG neurons was examined. We found that the extracel- lularly applied 17b-E2 inhibited voltage-gated total out- ward potassium currents; the effects were rapid, reversible, and concentration-dependent. Moreover, the membrane impermeable E2-BSA was as efficacious as 17b-E2, whereas 17a-E2 had no effect. 17b-E2-stimulated decrease in the potassium current was unaffected by treatment with ICI 182780 (classic estrogen receptor antagonist), actino- mycin D (RNA synthesis inhibitor), or cycloheximide (protein synthesis inhibitor). We also found that IA and IKDR were decreased after 17b-E2 application. 17b-E2 significantly shifted the activation curve for IA and IKDR channels in the hyperpolarizing direction. In conclusion, our results demonstrate that E2 inhibited voltage-gated K ?" @default.
• W3149263889 created "2021-04-13" @default.
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• W3149263889 date "2014-01-01" @default.
• W3149263889 modified "2023-09-27" @default.
• W3149263889 title "Effects of Estradiol on Voltage-Gated Potassium Channels in Mouse Dorsal Root Ganglion Neurons" @default.
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