FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3149336162> ?p ?o ?g. }

• W3149336162 endingPage "628" @default.
• W3149336162 startingPage "599" @default.
• W3149336162 abstract "Background Lifestyle therapy with resistance training is a potent measure to counteract age-related loss in muscle strength and mass. Unfortunately, many individuals fail to respond in the expected manner. This phenomenon is particularly common among older adults and those with chronic diseases (e.g. chronic obstructive pulmonary disease, COPD) and may involve endocrine variables such as vitamin D. At present, the effects of vitamin D supplementation on responses to resistance training remain largely unexplored. Methods Ninety-five male and female participants (healthy, n = 71; COPD, n = 24; age 68 ± 5 years) were randomly assigned to receive either vitamin D3 or placebo supplementation for 28 weeks in a double-blinded manner (latitude 61°N, September–May). Seventy-eight participants completed the RCT, which was initiated by 12 weeks of supplementation-only (two weeks with 10 000 IU/day, followed by 2000 IU/day), followed by 13 weeks of combined supplementation (2000 IU/day) and supervised whole-body resistance training (twice weekly), interspersed with testing and measurements. Outcome measures included multiple assessments of muscle strength (nvariables = 7), endurance performance (n = 6), and muscle mass (n = 3, legs, primary), as well as muscle quality (legs), muscle biology (m. vastus lateralis; muscle fibre characteristics, transcriptome), and health-related variables (e.g. visceral fat mass and blood lipid profile). For main outcome domains such as muscle strength and muscle mass, weighted combined factors were calculated from the range of singular assessments. Results Overall, 13 weeks of resistance training increased muscle strength (13% ± 8%), muscle mass (9% ± 8%), and endurance performance (one-legged, 23% ± 15%; whole-body, 8% ± 7%), assessed as weighted combined factors, and were associated with changes in health variables (e.g. visceral fat, −6% ± 21%; [LDL]serum, −4% ± 14%) and muscle tissue characteristics such as fibre type proportions (e.g. IIX, −3% points), myonuclei per fibre (30% ± 65%), total RNA/rRNA abundances (15%/6–19%), and transcriptome profiles (e.g. 312 differentially expressed genes). Vitamin D3 supplementation did not affect training-associated changes for any of the main outcome domains, despite robust increases in [25(OH)D]serum (∆49% vs. placebo). No conditional effects were observed for COPD vs. healthy or pre-RCT [25(OH)D]serum. In secondary analyses, vitamin D3 affected expression of gene sets involved in vascular functions in muscle tissue and strength gains in participants with high fat mass, which advocates further study. Conclusions Vitamin D3 supplementation did not affect muscular responses to resistance training in older adults with or without COPD." @default.
• W3149336162 created "2021-04-13" @default.
• W3149336162 creator A5000390904 @default.
• W3149336162 creator A5002228028 @default.
• W3149336162 creator A5003685243 @default.
• W3149336162 creator A5005623916 @default.
• W3149336162 creator A5009083067 @default.
• W3149336162 creator A5009879673 @default.
• W3149336162 creator A5013424976 @default.
• W3149336162 creator A5014228895 @default.
• W3149336162 creator A5014672145 @default.
• W3149336162 creator A5018212770 @default.
• W3149336162 creator A5022253237 @default.
• W3149336162 creator A5040663882 @default.
• W3149336162 creator A5056289112 @default.
• W3149336162 creator A5063952087 @default.
• W3149336162 creator A5066006786 @default.
• W3149336162 creator A5077900260 @default.
• W3149336162 creator A5079175384 @default.
• W3149336162 creator A5088945056 @default.
• W3149336162 date "2021-03-31" @default.
• W3149336162 modified "2023-10-18" @default.
• W3149336162 title "Vitamin D ₃ supplementation does not enhance the effects of resistance training in older adults" @default.
• W3149336162 cites W1240635074 @default.
• W3149336162 cites W1597957958 @default.
• W3149336162 cites W1809149742 @default.
• W3149336162 cites W1870980090 @default.
• W3149336162 cites W1877102901 @default.
• W3149336162 cites W1907865805 @default.
• W3149336162 cites W1945431751 @default.
• W3149336162 cites W1966576146 @default.
• W3149336162 cites W1970536654 @default.
• W3149336162 cites W1971030675 @default.
• W3149336162 cites W1978899849 @default.
• W3149336162 cites W1979655571 @default.
• W3149336162 cites W1982032046 @default.
• W3149336162 cites W1984351350 @default.
• W3149336162 cites W1991953699 @default.
• W3149336162 cites W1992388563 @default.
• W3149336162 cites W2000473280 @default.
• W3149336162 cites W2001850834 @default.
• W3149336162 cites W2004008756 @default.
• W3149336162 cites W2008495451 @default.
• W3149336162 cites W2008544163 @default.
• W3149336162 cites W2010457001 @default.
• W3149336162 cites W2014623158 @default.
• W3149336162 cites W2017890428 @default.
• W3149336162 cites W2027839256 @default.
• W3149336162 cites W2041758489 @default.
• W3149336162 cites W2042709851 @default.
• W3149336162 cites W2043365814 @default.
• W3149336162 cites W2045362882 @default.
• W3149336162 cites W2046362789 @default.
• W3149336162 cites W2049942632 @default.
• W3149336162 cites W2050907928 @default.
• W3149336162 cites W2051409263 @default.
• W3149336162 cites W2052109566 @default.
• W3149336162 cites W2057643886 @default.
• W3149336162 cites W2057960769 @default.
• W3149336162 cites W2066565006 @default.
• W3149336162 cites W2068122532 @default.
• W3149336162 cites W2072506507 @default.
• W3149336162 cites W2072930187 @default.
• W3149336162 cites W2073397713 @default.
• W3149336162 cites W2075111821 @default.
• W3149336162 cites W2077500520 @default.
• W3149336162 cites W2079690855 @default.
• W3149336162 cites W2079831502 @default.
• W3149336162 cites W2080377976 @default.
• W3149336162 cites W2085394455 @default.
• W3149336162 cites W2092410657 @default.
• W3149336162 cites W2092511022 @default.
• W3149336162 cites W2093545368 @default.
• W3149336162 cites W2097467471 @default.
• W3149336162 cites W2098306595 @default.
• W3149336162 cites W2099206288 @default.
• W3149336162 cites W2103544702 @default.
• W3149336162 cites W2103778438 @default.
• W3149336162 cites W2103784531 @default.
• W3149336162 cites W2104357394 @default.
• W3149336162 cites W2106357467 @default.
• W3149336162 cites W2108073731 @default.
• W3149336162 cites W2108729723 @default.
• W3149336162 cites W2109355833 @default.
• W3149336162 cites W2112323110 @default.
• W3149336162 cites W2113053613 @default.
• W3149336162 cites W2120962671 @default.
• W3149336162 cites W2124341792 @default.
• W3149336162 cites W2125078269 @default.
• W3149336162 cites W2130410032 @default.
• W3149336162 cites W2130850760 @default.
• W3149336162 cites W2131738855 @default.
• W3149336162 cites W2135082958 @default.
• W3149336162 cites W2136739903 @default.
• W3149336162 cites W2137046611 @default.
• W3149336162 cites W2142115426 @default.
• W3149336162 cites W2143366406 @default.
• W3149336162 cites W2143427836 @default.

• next