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• W3149337428 abstract "Current medicine for Alzheimer's disease (AD) cannot effectively reverse or block nerve injury. Traditional Chinese Medicine practice and research imply Aconiti lateralis Radix Praeparata (Fuzi) may meet this goal.Analysing the anti-AD effect of Fuzi and its potential molecular mechanism.AD model cells were treated with Fuzi in 0-300 mg/mL for 24 h in 37 °C. The cell viability (CV) and length of cell projections (LCP) for each group were observed, analysed, and standardised using control as a baseline (CVs and LCPs). The Fuzi and AD relevant genes were identified basing on databases, and the molecular mechanism of Fuzi anti-AD was predicted by network analysis.Experiment results showed that Fuzi in 0.4 mg/mL boosted LCP (LCPs = 1.2533, p ≤ 0.05), and in 1.6-100 mg/mL increased CV (CVs from 1.1673 to 1.3321, p ≤ 0.05). Bioinformatics analysis found 17 Fuzi target genes (relevant scores ≥ 20), showing strong AD relevant signals (RMS_p ≤ 0.05, related scores ≥ 5), enriched in the pathways regulating axon growth, synaptic plasticity, cell survival, proliferation, apoptosis, and death (p ≤ 0.05). Especially, GRIN1 and MAPK1 interacted with APP protein and located in the key point of the Alzheimer's disease pathway.These results suggest that Fuzi may have therapeutic and prevention potential in AD, and GRIN1 and MAPK1 may be the core of the pathways of the Fuzi anti-AD process. Fuzi should be studied more extensively, especially for the prevention of AD." @default.
• W3149337428 created "2021-04-13" @default.
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• W3149337428 date "2021-01-01" @default.
• W3149337428 modified "2023-10-05" @default.
• W3149337428 title "<i>Aconiti lateralis Radix Praeparata</i> inhibits Alzheimer’s disease by regulating the complex regulation network with the core of <i>GRIN1</i> and <i>MAPK1</i>" @default.
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• W3149337428 cites W1982436209 @default.
• W3149337428 cites W1989277387 @default.
• W3149337428 cites W1992604829 @default.
• W3149337428 cites W1999400659 @default.
• W3149337428 cites W2027537461 @default.
• W3149337428 cites W2033105784 @default.
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• W3149337428 cites W2114729479 @default.
• W3149337428 cites W2114926230 @default.
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• W3149337428 cites W2266996964 @default.
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• W3149337428 doi "https://doi.org/10.1080/13880209.2021.1900879" @default.
• W3149337428 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8018400" @default.
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• W3149337428 hasPublicationYear "2021" @default.
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