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- W3149337908 abstract "MicroRNAs were reported to be involved in the modulation of tumor development. The aim of our study was to investigate the effect of miR-205 on proliferation and apoptosis of laryngeal squamous cell carcinoma (LSCC) and seek associations between miR-205 and Bcl-2 using in vitro and in vivo methods. Real-time qPCR was used to analyze the expression of miR-205 in LSCC sam- ples and Hep-2 cell line. Apoptosis, cell cycle, and pro- liferation (MTT) assays were performed to test the apoptosis and proliferation of LSCC cells after miR-205 transfection. Bcl-2 expression in cells was assessed with Western blotting. The tumorigenicity of LSCC cells was evaluated in nude mice model. MiR-205 was significantly down-regulated in LSCC tissues compared to adjacent normal tissues. Lower expression of miR-205 was indi- cated to be statistically related with advanced clinical stage and T3-4 grades. We found that restoration of miR-205 down-regulated the proliferative markers of dihydrofolate reductase and proliferating cell nuclear antigen and apop- totic regulator of Bcl-2. The findings in vitro and in vivo showed miR-205 could suppress cell proliferation and induce cell apoptosis. In addition, Bcl-2 was identified as one of the direct targets of miR-205 in LSCC cells. These results suggest that miR-205 may play as a tumor sup- pressor in LSCC, probably by targeting Bcl-2 and serve as a potential target for therapeutic intervention." @default.
- W3149337908 created "2021-04-13" @default.
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- W3149337908 date "2014-01-01" @default.
- W3149337908 modified "2023-09-23" @default.
- W3149337908 title "MicroRNA-205 suppresses proliferation and promotes apoptosis in laryngeal squamous cell carcinoma" @default.
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