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- W3149353076 abstract "In order to elucidate cell toxicity of surfactants being detergent raw materials, as the main object of discussions, investigations have been carried out on demarcatability and permeability of cell membrane substances, and effects from energy converting reactions of mitochondria (Mt) in rat livers. Hemolysis of human red blood cells under the presence of standard soap increased with concentrations of subject substances and reaction time, having reached 100% in 60 minutes at a rate of 8 mg/l. Strength of hemolytic activity was identified easily from a comparison of 50% hemolysis inducing concentration (EC50) in each subject substance. With regard to respiratory control rate (RCR) in Mt, the respiratory activity decreased with an increase in the concentration of the standard soap. Strength of respiration inhibiting actions was identified from a comparison of 50% RCR inhibiting concentration (IC50) in each subject substance. The regression equation to show the correlation between the EC50 (Y) and the IC50 (X) of Mt was Y = -0.1198X + 25.345, the coefficient of correlation r = -0.0855, indicating very little correlation between them. The method used in the present study is useful for assessment of toxicity in different environment polluting substances to biological membranes. 28 refs., 8 figs., 2 tabs." @default.
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- W3149353076 date "1993-11-10" @default.
- W3149353076 modified "2023-09-27" @default.
- W3149353076 title "Effects of surfactants and related compounds on the functions of biological membranes and their application to toxicity assessment. Kakushu kaimen kasseizai no seitaimaku kino ni oyobosu sayo to dokusei eno oyo" @default.
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