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- W3149361572 abstract "背景 Mesangial hypercellularity 是一批评在人、试验性的 glomerular 疾病的早组织病理学说的发现。Hyperlipidemia 和脂蛋白的 glomerular 免职通常与 mesangial hypercellularity 被联系并且在 glomerular 疾病的发展起一个重要 pathobiological 作用。激活的细胞质的激活 mitogen 的蛋白质 kinase (MAPK ) 包括主要细胞外信号的调整蛋白质 kinase (英皇家空军之阶级最低之兵) ， c6月氨基终端的 kinase ( JNK )，和 p38 ，被认为到 translocate 进原子核并且激活与细胞生长和增长联系的各种各样的抄写因素和 protooncogenes 。脂蛋白(a)(Lp (a)) 被显示了刺激 mesangial 房间的增长，但是 Lp (a) 发信号的事件还没被描绘了。这研究的目的是调查涉及 Lp (a)的信号 transduction 小径导致的房间增长并且为 mesangial 房间 proliferation.Methods Lp (a)在细胞内部的发信号的小径为 Lp (a)的参予提供一条证据从与低密度脂蛋白( LDL )正在被对待的一个病人被孤立词首字母的脱落由密度坡度 ultracentrifugation 然后层析。人的 mesangial 房间(HMC ) 被顺序的 sieving 技术孤立并且在不同集中和时间路线与 Lp 刺激了(a) 。房间的 DNA 合成被测量由[~ 3H ] 为检测增长的 thymidine 加入。MAPK 家庭，包括的 ERK1/ERK2， JNK，和 p38 的所有三个成员的表示，和他们的 phosphorylation 被西方的弄污检测。结果 Lp (a) 能导致 HMC 的重要剂量依赖者增长。~ 3H-TdR 加入是 1.64" @default.
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- W3149361572 date "2010-01-01" @default.
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- W3149361572 title "Differential effect of three mitogen-activated protein kinases on lipoprotein （a）-induced human mesangial cell proliferation" @default.
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