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• W3149374630 endingPage "147462" @default.
• W3149374630 startingPage "147462" @default.
• W3149374630 abstract "Astrocytic injury responses are known to be influenced by the extracellular matrix (ECM). Astrocytes are also recognized as a source of extracellular vesicles (EVs) that can impact the activity and function of other astrocytes and cell types. Whether the ECM influences the function of astrocytic EVs in the context of wound recovery has not been previously studied. We report EVs from astrocytes cultured on varied ECM substrates are sufficient to elicit distinct injury responses in naive astrocytes that recapitulate the effects of the ECM of origin. When compared with wound recovery on control substrates, EVs from ECM-exposed astrocytes elicited accelerated rates of wound recovery that varied based on each ECM. When EVs were collected from IL-1β treated and ECM-exposed astrocyte cultures, we found that IL-1β arrested wound recovery in naive astrocytes treated with EVs from astrocytes cultured on ECM but adding EVs from IL-1β treated Tenascin-c-cultured astrocytes increased wound recovery. To confirm that ECM was a primary influence on these astrocytic EV functions, we tested the contribution of β1-integrin, a major integrin receptor for the ECM molecules tested in this study. We found that the β1-integrin inhibitor Ha2/5, resulted in EVs that significantly attenuated the wound recovery of naive astrocytes. This provides new information on the importance of culture substrates on astrocytic responses, EV functions and injury responses that may impact the understanding of astroglial responses related to ECM compositional differences in diverse physiological states." @default.
• W3149374630 created "2021-04-13" @default.
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• W3149374630 date "2021-07-01" @default.
• W3149374630 modified "2023-10-16" @default.
• W3149374630 title "Extracellular matrix influences astrocytic extracellular vesicle function in wound repair" @default.
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• W3149374630 doi "https://doi.org/10.1016/j.brainres.2021.147462" @default.
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• W3149374630 hasPublicationYear "2021" @default.
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