Matches in SemOpenAlex for { <https://semopenalex.org/work/W3149378152> ?p ?o ?g. }
- W3149378152 endingPage "104359" @default.
- W3149378152 startingPage "104359" @default.
- W3149378152 abstract "Conventional anti-tuberculosis (TB) therapies comprise lengthy antibiotic treatment regimens, exacerbated by multi-drug resistant and extensively drug resistant mycobacterial strains. We assessed the ability of all-trans retinoic acid (ATRA), as repurposed compound serving as host-directed therapy (HDT), to counteract the suppressive effects of myeloid-derived suppressor cells (MDSCs) obtained from active TB cases (untreated or during week one of treatment) on T-cell responsiveness. We show for the first time that MDSCs suppress non-specific T-cell activation and production of interleukin (IL)-2, IL-4, IL-13 and GM-CSF via contact-dependent mechanisms. ATRA treatment decreases MDSC frequency, but fails to mature MDSCs to non-suppressive, terminally differentiated myeloid cells and does not restore T-cell function or cytokine production in the presence of MDSCs. The impact of ATRA treatment on improved immunity, using the concentration tested here, is likely to be minimal, but further identification and development of MDSC-targeting TB host-directed therapies are warranted." @default.
- W3149378152 created "2021-04-13" @default.
- W3149378152 creator A5003619189 @default.
- W3149378152 creator A5018257487 @default.
- W3149378152 creator A5022339560 @default.
- W3149378152 creator A5022897595 @default.
- W3149378152 creator A5044818969 @default.
- W3149378152 creator A5055045521 @default.
- W3149378152 creator A5074511947 @default.
- W3149378152 creator A5080125776 @default.
- W3149378152 date "2021-06-01" @default.
- W3149378152 modified "2023-09-27" @default.
- W3149378152 title "Targeting of myeloid-derived suppressor cells by all-trans retinoic acid as host-directed therapy for human tuberculosis" @default.
- W3149378152 cites W1491146431 @default.
- W3149378152 cites W1518539840 @default.
- W3149378152 cites W1552212814 @default.
- W3149378152 cites W1576136791 @default.
- W3149378152 cites W1585754595 @default.
- W3149378152 cites W1591630593 @default.
- W3149378152 cites W1933912253 @default.
- W3149378152 cites W1972274031 @default.
- W3149378152 cites W1976566701 @default.
- W3149378152 cites W1983547790 @default.
- W3149378152 cites W1987446429 @default.
- W3149378152 cites W1992542859 @default.
- W3149378152 cites W1993232754 @default.
- W3149378152 cites W1994812075 @default.
- W3149378152 cites W2004150448 @default.
- W3149378152 cites W2004445332 @default.
- W3149378152 cites W2030284768 @default.
- W3149378152 cites W2038621149 @default.
- W3149378152 cites W2045219244 @default.
- W3149378152 cites W2046768931 @default.
- W3149378152 cites W2060727628 @default.
- W3149378152 cites W2075072767 @default.
- W3149378152 cites W2080847203 @default.
- W3149378152 cites W2114736117 @default.
- W3149378152 cites W2117358667 @default.
- W3149378152 cites W2120539661 @default.
- W3149378152 cites W2121847612 @default.
- W3149378152 cites W2128553155 @default.
- W3149378152 cites W2130815390 @default.
- W3149378152 cites W2135132221 @default.
- W3149378152 cites W2140187740 @default.
- W3149378152 cites W2141507915 @default.
- W3149378152 cites W2149360266 @default.
- W3149378152 cites W2156971530 @default.
- W3149378152 cites W2158853057 @default.
- W3149378152 cites W2312251574 @default.
- W3149378152 cites W2407345634 @default.
- W3149378152 cites W2471500324 @default.
- W3149378152 cites W2522432347 @default.
- W3149378152 cites W2568946517 @default.
- W3149378152 cites W2625763003 @default.
- W3149378152 cites W2733188787 @default.
- W3149378152 cites W2758171977 @default.
- W3149378152 cites W2766475728 @default.
- W3149378152 cites W2767225644 @default.
- W3149378152 cites W2773759063 @default.
- W3149378152 cites W2782485041 @default.
- W3149378152 cites W2798251250 @default.
- W3149378152 cites W2883559784 @default.
- W3149378152 cites W2913153613 @default.
- W3149378152 cites W2943585777 @default.
- W3149378152 doi "https://doi.org/10.1016/j.cellimm.2021.104359" @default.
- W3149378152 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8493473" @default.
- W3149378152 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33865151" @default.
- W3149378152 hasPublicationYear "2021" @default.
- W3149378152 type Work @default.
- W3149378152 sameAs 3149378152 @default.
- W3149378152 citedByCount "10" @default.
- W3149378152 countsByYear W31493781522021 @default.
- W3149378152 countsByYear W31493781522022 @default.
- W3149378152 countsByYear W31493781522023 @default.
- W3149378152 crossrefType "journal-article" @default.
- W3149378152 hasAuthorship W3149378152A5003619189 @default.
- W3149378152 hasAuthorship W3149378152A5018257487 @default.
- W3149378152 hasAuthorship W3149378152A5022339560 @default.
- W3149378152 hasAuthorship W3149378152A5022897595 @default.
- W3149378152 hasAuthorship W3149378152A5044818969 @default.
- W3149378152 hasAuthorship W3149378152A5055045521 @default.
- W3149378152 hasAuthorship W3149378152A5074511947 @default.
- W3149378152 hasAuthorship W3149378152A5080125776 @default.
- W3149378152 hasBestOaLocation W31493781521 @default.
- W3149378152 hasConcept C104317684 @default.
- W3149378152 hasConcept C126831891 @default.
- W3149378152 hasConcept C142724271 @default.
- W3149378152 hasConcept C159047783 @default.
- W3149378152 hasConcept C179185449 @default.
- W3149378152 hasConcept C203014093 @default.
- W3149378152 hasConcept C2777975735 @default.
- W3149378152 hasConcept C2779282312 @default.
- W3149378152 hasConcept C2781069245 @default.
- W3149378152 hasConcept C2781121885 @default.
- W3149378152 hasConcept C2994430510 @default.
- W3149378152 hasConcept C502942594 @default.
- W3149378152 hasConcept C54355233 @default.
- W3149378152 hasConcept C71924100 @default.