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- W3149381844 abstract "染色体 6p21.3 上的人的白细胞抗原(HLA ) 建筑群是在煽动性的肠疾病(IBD ) 的最广泛地学习的基因区域。到 IBD3 (6p21.1-23 ) 的连接的一致证据,包含 HLA 建筑群的一个区域,为两 Crohn 的疾病被表明了, ulcerative,和有疾病危险性和显型的很多个复制协会最近出现了。然而,尽管有这些努力为 IBD 遗体的 HLA 危险性基因(s) 逃犯,越过这个区域的强壮的连接不平衡,广泛的多型性和高基因密度的后果。这篇文章在 IBD 危险性和显型考察 HLA 复杂基因的角色的当前的知识,并且讨论当前限制这知识的翻译到临床的实践的因素。" @default.
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- W3149381844 date "2006-01-01" @default.
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- W3149381844 title "Genetics of inflammatory bowel disease: The role of the HLA complex" @default.
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