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- W3149399797 abstract "在肝细胞癌(HCC ) 的发生观察的惹人注目的性不同在 HCC 致病建议性荷尔蒙的一个重要角色。尽管研究在 HCC 象在 1980 年代，性荷尔蒙的精确角色和他们的受体的意义一样早开始了，仍然保持糟糕理解并且也许在 HCC 关于神经质的治疗的潜在的使用贡献当前的争吵。存在文学的全面评论揭示了在雌激素受体上与研究联系的几个缺点(嗯) 并且在正常的肝和 HCC 的雄激素受体(AR ) 。当 ERbeta 对碘氧基苯甲醚被识别时，这些缺点独自为 ERalpha 包括不太敏感的受体 ligand 绑定试金和免疫组织化学研究的使用直到 1996。为研究利用的 HCC 的动物模型主要基于有到导致病毒的 HCC 致病的更少的类似的导致化学药品的 hepatocarcinogenesis。然而，在肝细胞瘤房间的最近的在试管内研究包括相互作用为关键细胞的过程的神经质的规定提供更新的卓见嗯并且有病毒的蛋白质的 AR。考虑到上述事实，在正常的肝和 HCC 对性荷尔蒙和他们的受体的详细调查有迫切需要。在这评论，我们系统地在从在试管内获得的正常的肝和 HCC 介绍在雄激素，雌激素和他们的受体上当前可得到的信息，在活体内试验性的模型和临床的研究。这个信息将指导基本的未来和临床的研究在知识衔接差距在 HCC 探索神经质的治疗的治疗学的潜力。" @default.
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- W3149399797 date "2008-01-01" @default.
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