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- W3149435581 abstract "This study aimed to develop novel galactosy- lated cholesterol modified-glycol chitosan (Gal-CHGC) micelles for targeting delivery of doxorubicin (DOX) in live cancer cells. Three kinds of Gal-CHGC conjugates were synthesized and characterized. The mean particle size and critical aggregation concentration of these polymeric micelles increased with the increase of galactose substitu- tion degree. The DOX-loaded micelles were prepared by an o/w method. The mean diameters of DOX-loaded galac- tosylated micelles were in the range of 387-497 nm. DOX released from drug-loaded micelles displayed a biphasic way. Cellular uptake studies demonstrated that DOX-loa- ded galactosylated micelles could enhance the uptake of DOX into HepG2 cells. Moreover, the cytotoxicity of DOX-loaded galactosylated micelles against HepG2 cells significantly improved in contrast with free DOX and DOX-loaded micelles without galactosylation. These results suggested that Gal-CHGC micelles could be a potential carrier for hepatoma-targeting drug delivery." @default.
- W3149435581 created "2021-04-13" @default.
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- W3149435581 date "2014-01-01" @default.
- W3149435581 modified "2023-09-27" @default.
- W3149435581 title "Preparation and characterization of galactosylated glycol chitosan micelles and its potential use for hepatoma-targeting delivery of doxorubicin" @default.
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