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- W3149440045 abstract "Hepatocellular carcinoma (HCC) is one of the world's most aggressive diseases and carries a poor prog- nosis for patients. Recent evidence suggests that HCC is organized by cancer stem cells (CSCs), which are a subset of cells with stem cell-like features. CSCs are considered a pivotal target for the eradication of cancer, and liver CSCs have been investigated using various stem cell markers. Several hepatic stem/progenitor markers have been shown to be useful for isolating putative CSCs from HCC, although the expression patterns and phenotypic diversity of CSCs purified by these markers remain obscure. Recently, we found that liver CSCs defined by different markers show unique features of tumorigenicity and metastasis, with phenotypes closely associated with com- mitted liver lineages. Furthermore, our data suggest that these distinct CSCs collaborate to orchestrate the tumori- genicity and metastasis of HCC. In this review article, we summarize the recent advances in understanding the path- ogenesis and heterogeneity of liver CSCs." @default.
- W3149440045 created "2021-04-13" @default.
- W3149440045 creator A5027841180 @default.
- W3149440045 date "2014-01-01" @default.
- W3149440045 modified "2023-09-24" @default.
- W3149440045 title "Orchestration of hepatocellular carcinoma development by diverse liver cancer stem cells" @default.
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