FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3149454756> ?p ?o ?g. }

• W3149454756 endingPage "691" @default.
• W3149454756 startingPage "681" @default.
• W3149454756 abstract "Current preclinical therapeutic strategies involving nanomedicine require increasingly sophisticated nanosystems and the characterization of the complexity of such nanoassemblies is becoming a major issue. Accurate characterization is often the factor that can accelerate the translational approaches of nanomedicines and their pharmaceutical development to reach the clinic faster. We conducted a case study involving the adsorption of the NFL-TBS.40-63 (NFL) peptide (derived from neurofilaments) to the surface of lipid nanocapsules (LNCs) (a combined nanosystem used to target glioblastoma cells) to develop an analytical approach combining the separation and the quantification in a single step, leading to the characterization of the proportion of free peptide and thus the proportion of peptide adsorbed to the lipid nanocapsule surface.LNC suspensions, NFL peptide solution and LNC/NFL peptide mixtures were characterized using a Size-Exclusion Chromatography method (with a chromatographic apparatus). In addition, this method was compared to centrifugal-filtration devices, currently used in literature for this case study.Combining the steps for separation and characterization in one single sequence improved the accuracy and robustness of the data and led to reproducible results. Moreover the data deviation observed for the centrifugal-filtration devices demonstrated the limits for this increasingly used characterization approach, explained by the poor separation quality and highlighting the importance for the method optimization. The high potential of the technique was shown, proving that H-bond and/or electrostatic interactions mediate adsorption of the NFL peptide to the surface of LNCs.Used only as a characterization tool, the process using chromatographic apparatus is less time and solvent consuming than classical Size-Exclusion Chromatography columns only used for separation. It could be a promising tool for the scientific community for characterizing the interactions of other combinations of nanosystems and active biological agents." @default.
• W3149454756 created "2021-04-13" @default.
• W3149454756 creator A5003727171 @default.
• W3149454756 creator A5011554123 @default.
• W3149454756 creator A5013707913 @default.
• W3149454756 creator A5029250565 @default.
• W3149454756 creator A5031276108 @default.
• W3149454756 creator A5035636559 @default.
• W3149454756 creator A5036510036 @default.
• W3149454756 creator A5057987159 @default.
• W3149454756 date "2021-04-01" @default.
• W3149454756 modified "2023-10-13" @default.
• W3149454756 title "Characterization of Biological Material Adsorption to the Surface of Nanoparticles without a Prior Separation Step: a Case Study of Glioblastoma-Targeting Peptide and Lipid Nanocapsules" @default.
• W3149454756 cites W1205374584 @default.
• W3149454756 cites W1942678791 @default.
• W3149454756 cites W2004096773 @default.
• W3149454756 cites W2011657694 @default.
• W3149454756 cites W2016755398 @default.
• W3149454756 cites W2035270319 @default.
• W3149454756 cites W2036690324 @default.
• W3149454756 cites W2050063412 @default.
• W3149454756 cites W2072185481 @default.
• W3149454756 cites W2072453922 @default.
• W3149454756 cites W2074137831 @default.
• W3149454756 cites W2080078119 @default.
• W3149454756 cites W2087963727 @default.
• W3149454756 cites W2126209532 @default.
• W3149454756 cites W2210387796 @default.
• W3149454756 cites W2291783477 @default.
• W3149454756 cites W2329944158 @default.
• W3149454756 cites W2338977647 @default.
• W3149454756 cites W2476767087 @default.
• W3149454756 cites W2734776326 @default.
• W3149454756 cites W2792625060 @default.
• W3149454756 cites W2804106046 @default.
• W3149454756 cites W2807847480 @default.
• W3149454756 cites W2808218231 @default.
• W3149454756 cites W2896523722 @default.
• W3149454756 cites W2897852978 @default.
• W3149454756 cites W2900942887 @default.
• W3149454756 cites W2901601715 @default.
• W3149454756 cites W2908870723 @default.
• W3149454756 cites W2914736237 @default.
• W3149454756 cites W2917688997 @default.
• W3149454756 cites W2954437208 @default.
• W3149454756 cites W2967151052 @default.
• W3149454756 cites W2989057790 @default.
• W3149454756 cites W2990574737 @default.
• W3149454756 cites W2990912661 @default.
• W3149454756 cites W2991707285 @default.
• W3149454756 cites W2996361080 @default.
• W3149454756 cites W3005220199 @default.
• W3149454756 doi "https://doi.org/10.1007/s11095-021-03034-8" @default.
• W3149454756 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8026175" @default.
• W3149454756 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33829340" @default.
• W3149454756 hasPublicationYear "2021" @default.
• W3149454756 type Work @default.
• W3149454756 sameAs 3149454756 @default.
• W3149454756 citedByCount "10" @default.
• W3149454756 countsByYear W31494547562021 @default.
• W3149454756 countsByYear W31494547562022 @default.
• W3149454756 countsByYear W31494547562023 @default.
• W3149454756 crossrefType "journal-article" @default.
• W3149454756 hasAuthorship W3149454756A5003727171 @default.
• W3149454756 hasAuthorship W3149454756A5011554123 @default.
• W3149454756 hasAuthorship W3149454756A5013707913 @default.
• W3149454756 hasAuthorship W3149454756A5029250565 @default.
• W3149454756 hasAuthorship W3149454756A5031276108 @default.
• W3149454756 hasAuthorship W3149454756A5035636559 @default.
• W3149454756 hasAuthorship W3149454756A5036510036 @default.
• W3149454756 hasAuthorship W3149454756A5057987159 @default.
• W3149454756 hasBestOaLocation W31494547561 @default.
• W3149454756 hasConcept C150394285 @default.
• W3149454756 hasConcept C15083742 @default.
• W3149454756 hasConcept C155672457 @default.
• W3149454756 hasConcept C171250308 @default.
• W3149454756 hasConcept C178790620 @default.
• W3149454756 hasConcept C181199279 @default.
• W3149454756 hasConcept C185592680 @default.
• W3149454756 hasConcept C192562407 @default.
• W3149454756 hasConcept C193363816 @default.
• W3149454756 hasConcept C204399865 @default.
• W3149454756 hasConcept C2779281246 @default.
• W3149454756 hasConcept C2780841128 @default.
• W3149454756 hasConcept C43617362 @default.
• W3149454756 hasConcept C55493867 @default.
• W3149454756 hasConceptScore W3149454756C150394285 @default.
• W3149454756 hasConceptScore W3149454756C15083742 @default.
• W3149454756 hasConceptScore W3149454756C155672457 @default.
• W3149454756 hasConceptScore W3149454756C171250308 @default.
• W3149454756 hasConceptScore W3149454756C178790620 @default.
• W3149454756 hasConceptScore W3149454756C181199279 @default.
• W3149454756 hasConceptScore W3149454756C185592680 @default.
• W3149454756 hasConceptScore W3149454756C192562407 @default.
• W3149454756 hasConceptScore W3149454756C193363816 @default.
• W3149454756 hasConceptScore W3149454756C204399865 @default.
• W3149454756 hasConceptScore W3149454756C2779281246 @default.
• W3149454756 hasConceptScore W3149454756C2780841128 @default.

• next