Matches in SemOpenAlex for { <https://semopenalex.org/work/W3149457971> ?p ?o ?g. }
- W3149457971 endingPage "119450" @default.
- W3149457971 startingPage "119450" @default.
- W3149457971 abstract "Although excessive fat and caffeine intake are independent risk factors for bone microstructural and functional disturbances, their association remains overlooked. Thus, we investigated the impact of high-fat diet (HFD) and caffeine alone and combined on serum lipid profile, bone microstructure, micromineral distribution and biomechanical properties. Forty female C57BL/6 mice were randomized into 4 groups daily treated for seventeen weeks with standard diet (SD) or HFD (cafeteria diet) alone or combined with 50 mg/kg caffeine. The association between HFD and caffeine reduced the weight gain compared to animals receiving HFD alone. Caffeine alone or combined with HFD increases total and HDL cholesterol circulating levels. HFD also reduced calcium, phosphorus and magnesium bone levels compared to the groups receiving SD, and this reduction was aggravated by caffeine coadministration. From biomechanical assays, HFD combined with caffeine increased bending strength and stiffness of tibia, a finding aligned with the marked microstructural remodeling of the cortical and cancellous bone in animals receiving this combination. Our findings indicated that HFD and caffeine interact to induce metabolic changes and bone microstructural remodeling, which are potentially related to bone biomechanical adaptations in response to HFD and caffeine coadministration." @default.
- W3149457971 created "2021-04-13" @default.
- W3149457971 creator A5010215972 @default.
- W3149457971 creator A5015983451 @default.
- W3149457971 creator A5018206064 @default.
- W3149457971 creator A5029098126 @default.
- W3149457971 creator A5029107033 @default.
- W3149457971 creator A5032798947 @default.
- W3149457971 creator A5040819065 @default.
- W3149457971 creator A5046165045 @default.
- W3149457971 creator A5050417813 @default.
- W3149457971 creator A5065357903 @default.
- W3149457971 creator A5072457058 @default.
- W3149457971 date "2021-07-01" @default.
- W3149457971 modified "2023-10-14" @default.
- W3149457971 title "High-fat diet and caffeine interact to modulate bone microstructure and biomechanics in mice" @default.
- W3149457971 cites W1508594218 @default.
- W3149457971 cites W1571883619 @default.
- W3149457971 cites W1716466693 @default.
- W3149457971 cites W1769803401 @default.
- W3149457971 cites W1907784997 @default.
- W3149457971 cites W1919453611 @default.
- W3149457971 cites W1955588589 @default.
- W3149457971 cites W1963633905 @default.
- W3149457971 cites W1965682512 @default.
- W3149457971 cites W1977600149 @default.
- W3149457971 cites W1980740451 @default.
- W3149457971 cites W1982703569 @default.
- W3149457971 cites W1998394279 @default.
- W3149457971 cites W2000981975 @default.
- W3149457971 cites W2009092353 @default.
- W3149457971 cites W2014228620 @default.
- W3149457971 cites W2014280483 @default.
- W3149457971 cites W2023868586 @default.
- W3149457971 cites W2029485666 @default.
- W3149457971 cites W2037869778 @default.
- W3149457971 cites W2052570402 @default.
- W3149457971 cites W2059007200 @default.
- W3149457971 cites W2064669034 @default.
- W3149457971 cites W2066749771 @default.
- W3149457971 cites W2068469481 @default.
- W3149457971 cites W2083205671 @default.
- W3149457971 cites W2086859574 @default.
- W3149457971 cites W2093420192 @default.
- W3149457971 cites W2099540110 @default.
- W3149457971 cites W2107672934 @default.
- W3149457971 cites W2108576543 @default.
- W3149457971 cites W2120756383 @default.
- W3149457971 cites W2121072209 @default.
- W3149457971 cites W2121661159 @default.
- W3149457971 cites W2122296834 @default.
- W3149457971 cites W2145615219 @default.
- W3149457971 cites W2152196964 @default.
- W3149457971 cites W2152345083 @default.
- W3149457971 cites W2154408257 @default.
- W3149457971 cites W2155413431 @default.
- W3149457971 cites W2157261598 @default.
- W3149457971 cites W2165424279 @default.
- W3149457971 cites W2191343050 @default.
- W3149457971 cites W2198095015 @default.
- W3149457971 cites W2256257390 @default.
- W3149457971 cites W2295263126 @default.
- W3149457971 cites W2360458704 @default.
- W3149457971 cites W2553674183 @default.
- W3149457971 cites W2562045227 @default.
- W3149457971 cites W2594757151 @default.
- W3149457971 cites W2605964591 @default.
- W3149457971 cites W2734005393 @default.
- W3149457971 cites W2737498334 @default.
- W3149457971 cites W2742365807 @default.
- W3149457971 cites W2755416660 @default.
- W3149457971 cites W2766001749 @default.
- W3149457971 cites W2772521804 @default.
- W3149457971 cites W2778170101 @default.
- W3149457971 cites W2779484206 @default.
- W3149457971 cites W2802554033 @default.
- W3149457971 cites W2883902554 @default.
- W3149457971 cites W2892952713 @default.
- W3149457971 cites W2907538400 @default.
- W3149457971 cites W2909867458 @default.
- W3149457971 cites W2912147854 @default.
- W3149457971 cites W2981762405 @default.
- W3149457971 cites W949018678 @default.
- W3149457971 doi "https://doi.org/10.1016/j.lfs.2021.119450" @default.
- W3149457971 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33798548" @default.
- W3149457971 hasPublicationYear "2021" @default.
- W3149457971 type Work @default.
- W3149457971 sameAs 3149457971 @default.
- W3149457971 citedByCount "2" @default.
- W3149457971 countsByYear W31494579712021 @default.
- W3149457971 countsByYear W31494579712022 @default.
- W3149457971 crossrefType "journal-article" @default.
- W3149457971 hasAuthorship W3149457971A5010215972 @default.
- W3149457971 hasAuthorship W3149457971A5015983451 @default.
- W3149457971 hasAuthorship W3149457971A5018206064 @default.
- W3149457971 hasAuthorship W3149457971A5029098126 @default.
- W3149457971 hasAuthorship W3149457971A5029107033 @default.
- W3149457971 hasAuthorship W3149457971A5032798947 @default.