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- W3149472401 abstract "Aim:To investigate whether selenite,a known antioxidant,could decrease the activation of apoptosis signal regulating kinase 1/c-jun N-terminal kinase(ASK1/ JNK)signaling cascade in cerebral ischemia/reperfusion(I/R)by activating the phosphatidylinositol 3-kinase(PI3K)/AKT pathway in rat hippocampi,and the neuroprotective effect of selenite against ischemic injury after 15 min of transient brain ischemia.Methods:Transient global brain ischemia was induced by 4-vessel occlusion into adult male Sprague-Dawley rats weighing 250-300 g.The rats were pretreated only with selenite(0.3 mg/kg dissolved in 0.9% saline)every 24 h for 7 d by means of intravenous injection of the tail or combined with LY294002 from d 5 by left cerebral ventricle injection before surgery.Results:Selenite significantly increased AKT 1 activation and decreased the activation of ASK1/ JNK cascade via phosphorylating ASK1 at Ser-83 residue by AKT1 during early reperfusion after 15 min transient global brain ischemia.On the contrary,com- bined pretreatment of the rats with LY294002(a specific PI3K inhibitor)and selen- ite significantly inhibited the effects solely with selenite.Conclusion:The activa- tion of the pro-apoptotic ASK1/JNK cascade,which is closely associated with oxidative stress,could be suppressed by selenite through activating the anti- apoptotic PI3K/AKT pathway during early reperfusion after cerebral ischemia in rat hippocampi." @default.
- W3149472401 created "2021-04-13" @default.
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- W3149472401 date "2007-01-01" @default.
- W3149472401 modified "2023-09-28" @default.
- W3149472401 title "Neuroprotection of selenite against ischemic brain injury through negatively regulating early activation of ASK1/JNK cascade via activation of PI3K/AKT pathway" @default.
- W3149472401 hasPublicationYear "2007" @default.
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