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- W3149484435 abstract "Three-dimensional (3D) organoids are a novel tool to model epithelial cell biology and human diseases of the esophagus. 3D organoid culture systems have been utilized to investigate the pathobiology of esophageal cancer, including both squamous cell carcinoma and adenocarcinoma. Additional organoid-based approaches for study of esophageal development and benign esophageal diseases have provided key insights into esophageal keratinocyte differentiation and mucosal regeneration. These investigations have implications for the identification of esophageal cancer stem cells, as well as the potential to halt malignant progression through induction of differentiation pathways. Patient-derived organoids (PDOs) from human tissue samples allow for unique and faithful in vitro modeling of esophageal cancers, and provide an exciting platform for investigation into personalized medicine and targeted treatment approaches, as well as new models for understanding therapy resistance and recurrent disease. Future directions include high-throughput genomic screening using PDOs, and study of tumor-microenvironmental interactions through co-culture with immune and stromal cells and novel extracellular matrix complexes." @default.
- W3149484435 created "2021-04-13" @default.
- W3149484435 creator A5022807186 @default.
- W3149484435 creator A5023204976 @default.
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- W3149484435 creator A5052023689 @default.
- W3149484435 creator A5059326174 @default.
- W3149484435 creator A5078659652 @default.
- W3149484435 date "2021-07-01" @default.
- W3149484435 modified "2023-10-18" @default.
- W3149484435 title "Understanding the cellular origin and progression of esophageal cancer using esophageal organoids" @default.
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