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- W3149515723 abstract "The present study aimed to investigate the effects of humanin (HN) on primary cortical neuronal apoptosis induced by Aβ31-35,and explore the potential mechanisms.Cultured cortical neurons were pretreated with different concentrations of HN (5,10,20 μmol/L) for different time period (0,8 and 16 h) respectively,and then exposed to Aβ31-35 (25 μmol/L) for additional 24 h and the neuronal apoptosis was examined by morphological analysis,flow cytometric assays and TUNEL staining.Caspase activities were measured using a spectrophotometer.Bax expression was measured by Western blot.The results were as follows.(1) Pretreatment with HN (20 μmol/L) for 16 h significantly prevented Aβ31-35-induced apoptosis in cortical neurons;(2) HN significantly decreased Aβ31-35-induced elevation of caspase-3 and -9 activities;(3) HN suppressed Aβ31-35-induced translocation of Bax from the cytosol to mitochondria,but had no effect on overall Bax expression.In conclusions,HN attenuated Aβ31-35-induced cortical neuronal apoptosis by blocking intrinsic caspase-dependent apoptotic pathways." @default.
- W3149515723 created "2021-04-13" @default.
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- W3149515723 date "2010-01-01" @default.
- W3149515723 modified "2023-09-24" @default.
- W3149515723 title "Humanin protects neurons against apoptosis induced by Aβ_(31-35) through suppression of intrinsic pathway" @default.
- W3149515723 hasPublicationYear "2010" @default.
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