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• W3149529787 abstract "Obesity has become a global public health problem associated with complications including type 2 diabetes, cardiovascular disease, and several cancers. Adipocyte differentiation (adipogenesis) plays an impor- tant role in obesity and energy homeostasis. Adipose tissue secretes multiple cytokines and adipokines which can cause the complications of obesity, especially insulin resistance. TNF-a, IL-6, leptin, and resistin have been identified as the main regulators of obesity and insulin activity. miR-378 is highly induced during adipogenesis and has been reported to be positively regulated in adipo- genesis. In the current study, matured human adipocytes were treated with TNF-a, IL-6, leptin, or resistin on the 15th day after the induction of human pre-adipocyte dif- ferentiation. We demonstrated that TNF-a, IL-6, and leptin upregulated miR-378 expression indicating that miR-378 probably is a novel mediator in the development of insulin resistance related to obesity." @default.
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• W3149529787 date "2014-01-01" @default.
• W3149529787 modified "2023-09-27" @default.
• W3149529787 title "TNF-a, IL-6, and Leptin Increase the Expression of miR-378, an Adipogenesis-Related microRNA in Human Adipocytes" @default.
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• W3149529787 hasPublicationYear "2014" @default.
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