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- W3149532406 abstract "Objective To investigate the association of the T(-344)C polymorphism of aldosterone synthase gene CYP11B 2 with essential hypertension in Xinjiang Kazakh isolated population. Methods The study covered 186 hypertensives and 168 normotensive controls in Xinjiang Kazakh population. The segment of CYP11B 2 was amplified from DNA by polymerase chain reaction(PCR). The PCR products were digested by restriction endonuclease. Results The frequencies of C and T in hypertensive group(0.45 and 0.55) were not significantly different from those in the control group(0.43 and 0.57;χ 2=0.380, P =0.537) .The frequencies of CYP11B 2 genotypes of CC,CT and TT were 0.20,0 50 and 0.30 in hypertensives respectively, and 0.12,0.61 and 0.27 in controls respectively. There was no significant difference in genotypes between hypertensive group and normotensive group(χ 2=4.838, P =0 089). But the frequencies of CC genotype were higher in the female hypertensives than in the normotensive controls (χ 2=6.104, P 0.05). Conclusion The results suggested that the T(-344)C polymorphism of CYP11B 2 gene may be associated with hypertension in female Kazakh population of Xinjiang Barlikun area." @default.
- W3149532406 created "2021-04-13" @default.
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- W3149532406 date "2004-01-01" @default.
- W3149532406 modified "2023-09-25" @default.
- W3149532406 title "Association of the T(-344)C polymorphism of aldosterone synthase gene CYP11B_2 with essential hypertension in Xinjiang Kazakh isolated group" @default.
- W3149532406 hasPublicationYear "2004" @default.
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