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- W3149563160 abstract "在人的结肠癌(HCT116 ) 的 apoptosis 调查细胞外的调整信号的 kinase (英皇家空军之阶级最低之兵) 的角色的目的房间。在 HCT116 房间以后的方法是有特定的英皇家空军之阶级最低之兵禁止者( U0126 )或特定的 siRNA 的 pretreated 并且为 24 h 暴露了到 10 mmol/L 钠丁酸盐( NaBT )，他们的 apoptosis 被流动 cytometry 检测， SphK2 的层次和英皇家空军之阶级最低之兵蛋白质被西方的污点测量，并且 SphK2 的 translocation 是由 immunofluorescence 显微镜学的 assayed 。结果 U0126 和为 SphK2 特定的 siRNAs 阻止原子核接近了 SphK2 的出口到细胞质并且增加了跟随 NaBT 暴露的 HCT116 房间的 apoptosis。PKD 的在表示上减少了 HCT116 房间的导致 NaBT 的 apoptosis，它被 U0126 颠倒。而且，有组成地激活的 PKD plasmids 的 HCT116 房间的 transfection 恢复了 SphK2 的堵住 U0126 的出口。结论英皇家空军之阶级最低之兵由 modulating PKD 调整 SphK2 的出口和 HCT116 房间的 apoptosis。这些分子的调整可以帮助增加结肠癌房间的敏感到生理的反冒号癌症代理人， NaBT。" @default.
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- W3149563160 date "2014-01-01" @default.
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- W3149563160 title "Sodium Butyrate Induces Apoptosis of Human Colon Cancer Cells by Modulating ERK and Sphingosine Kinase 2" @default.
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