FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3149578766> ?p ?o ?g. }

• W3149578766 endingPage "1617" @default.
• W3149578766 startingPage "1617" @default.
• W3149578766 abstract "Introduction: Recurrence of hepatocellular carcinoma (rHCC) after liver transplantation (LT) is associated with limited survival. Therefore, identification of factors that prolong survival in these patients is of great interest. Surgical resection, radiotherapy, and transarterial chemoembolization (TACE) are established interventions to improve outcomes in these patients; however, the impact of immunosuppression is unknown. Methods: All patients diagnosed with rHCC in the follow-up after LT were identified from a database of liver recipients transplanted between 1988 and 2019 at our institution (Charité Universitätsmedizin Berlin, Germany). Based on the immunosuppressive regimen following diagnosis of rHCC and the oncological treatment approach, survival analysis was performed. Results: Among 484 patients transplanted for HCC, 112 (23.1%) developed rHCC in the follow-up. Recurrent HCC was diagnosed at a median interval of 16.0 months (range 1.0–203.0), with the majority presenting early after transplantation (63.0%, <2 years). Median survival after rHCC diagnosis was 10.6 months (0.3–228.7). Reduction of immunosuppression was associated with improved survival, particularly in patients with palliative treatment (8.4 versus 3.0 months). In addition, greater reduction of immunosuppression seemed to be associated with greater prolongation of survival. Graft rejection after reduction was uncommon (n = 7, 6.8%) and did not result in any graft loss. Patients that underwent surgical resection showed improved survival rates (median 19.5 vs. 8.7 months). Conclusion: Reduction of immunosuppressive therapy after rHCC diagnosis is associated with prolonged survival in LT patients. Therefore, reduction of immunosuppression should be an early intervention following diagnosis. In addition, surgical resection should be attempted, if technically feasible and oncologically meaningful." @default.
• W3149578766 created "2021-04-13" @default.
• W3149578766 creator A5043718903 @default.
• W3149578766 creator A5050190020 @default.
• W3149578766 creator A5053351775 @default.
• W3149578766 creator A5054567084 @default.
• W3149578766 creator A5054668912 @default.
• W3149578766 creator A5066753190 @default.
• W3149578766 creator A5071991150 @default.
• W3149578766 creator A5076322082 @default.
• W3149578766 creator A5083825910 @default.
• W3149578766 creator A5085883112 @default.
• W3149578766 date "2021-03-31" @default.
• W3149578766 modified "2023-10-17" @default.
• W3149578766 title "Minimization of Immunosuppressive Therapy Is Associated with Improved Survival of Liver Transplant Patients with Recurrent Hepatocellular Carcinoma" @default.
• W3149578766 cites W1559113656 @default.
• W3149578766 cites W1886706265 @default.
• W3149578766 cites W1964829819 @default.
• W3149578766 cites W1976082980 @default.
• W3149578766 cites W2021324347 @default.
• W3149578766 cites W2038888556 @default.
• W3149578766 cites W2057587361 @default.
• W3149578766 cites W2072413179 @default.
• W3149578766 cites W2091651967 @default.
• W3149578766 cites W2091960470 @default.
• W3149578766 cites W2115448469 @default.
• W3149578766 cites W2170840607 @default.
• W3149578766 cites W2173253647 @default.
• W3149578766 cites W2179507467 @default.
• W3149578766 cites W2235002440 @default.
• W3149578766 cites W2329369787 @default.
• W3149578766 cites W2411494223 @default.
• W3149578766 cites W2479602527 @default.
• W3149578766 cites W2509069022 @default.
• W3149578766 cites W2512460450 @default.
• W3149578766 cites W2587718399 @default.
• W3149578766 cites W2608100235 @default.
• W3149578766 cites W2762353311 @default.
• W3149578766 cites W2785259657 @default.
• W3149578766 cites W2905029695 @default.
• W3149578766 cites W2926646909 @default.
• W3149578766 cites W2972327049 @default.
• W3149578766 cites W2973851184 @default.
• W3149578766 cites W2988471260 @default.
• W3149578766 cites W2999203814 @default.
• W3149578766 cites W3013340994 @default.
• W3149578766 cites W3036721121 @default.
• W3149578766 cites W3080289844 @default.
• W3149578766 cites W3083759464 @default.
• W3149578766 cites W3104158967 @default.
• W3149578766 doi "https://doi.org/10.3390/cancers13071617" @default.
• W3149578766 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8037838" @default.
• W3149578766 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33807392" @default.
• W3149578766 hasPublicationYear "2021" @default.
• W3149578766 type Work @default.
• W3149578766 sameAs 3149578766 @default.
• W3149578766 citedByCount "8" @default.
• W3149578766 countsByYear W31495787662021 @default.
• W3149578766 countsByYear W31495787662022 @default.
• W3149578766 countsByYear W31495787662023 @default.
• W3149578766 crossrefType "journal-article" @default.
• W3149578766 hasAuthorship W3149578766A5043718903 @default.
• W3149578766 hasAuthorship W3149578766A5050190020 @default.
• W3149578766 hasAuthorship W3149578766A5053351775 @default.
• W3149578766 hasAuthorship W3149578766A5054567084 @default.
• W3149578766 hasAuthorship W3149578766A5054668912 @default.
• W3149578766 hasAuthorship W3149578766A5066753190 @default.
• W3149578766 hasAuthorship W3149578766A5071991150 @default.
• W3149578766 hasAuthorship W3149578766A5076322082 @default.
• W3149578766 hasAuthorship W3149578766A5083825910 @default.
• W3149578766 hasAuthorship W3149578766A5085883112 @default.
• W3149578766 hasBestOaLocation W31495787661 @default.
• W3149578766 hasConcept C126322002 @default.
• W3149578766 hasConcept C141071460 @default.
• W3149578766 hasConcept C2776283816 @default.
• W3149578766 hasConcept C2778019345 @default.
• W3149578766 hasConcept C2779609443 @default.
• W3149578766 hasConcept C2780252810 @default.
• W3149578766 hasConcept C2781413609 @default.
• W3149578766 hasConcept C2911091166 @default.
• W3149578766 hasConcept C509974204 @default.
• W3149578766 hasConcept C71924100 @default.
• W3149578766 hasConcept C90924648 @default.
• W3149578766 hasConceptScore W3149578766C126322002 @default.
• W3149578766 hasConceptScore W3149578766C141071460 @default.
• W3149578766 hasConceptScore W3149578766C2776283816 @default.
• W3149578766 hasConceptScore W3149578766C2778019345 @default.
• W3149578766 hasConceptScore W3149578766C2779609443 @default.
• W3149578766 hasConceptScore W3149578766C2780252810 @default.
• W3149578766 hasConceptScore W3149578766C2781413609 @default.
• W3149578766 hasConceptScore W3149578766C2911091166 @default.
• W3149578766 hasConceptScore W3149578766C509974204 @default.
• W3149578766 hasConceptScore W3149578766C71924100 @default.
• W3149578766 hasConceptScore W3149578766C90924648 @default.
• W3149578766 hasIssue "7" @default.
• W3149578766 hasLocation W31495787661 @default.
• W3149578766 hasLocation W31495787662 @default.
• W3149578766 hasLocation W31495787663 @default.

• next