FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3149619011> ?p ?o ?g. }

• W3149619011 abstract "Abstract Stem cell niche is regulated by intrinsic and extrinsic factors. In the Drosophila testis, cyst stem cells (CySCs) support the differentiation of germline stem cells (GSCs). However, the underlying mechanisms remain unclear. In this study, we found that somatic CG6015 is required for CySC maintenance and GSC differentiation in a Drosophila model. Knockdown of CG6015 in CySCs caused aberrant activation of dpERK in undifferentiated germ cells in the Drosophila testis, and disruption of key downstream targets of EGFR signaling (Dsor1 and rl) in CySCs results in a phenotype resembling that of CG6015 knockdown. CG6015, Dsor1, and rl are essential for the survival of Drosophila cell line Schneider 2 (S2) cells. Our data showed that somatic CG6015 regulates CySC maintenance and GSC differentiation via EGFR signaling, and inhibits aberrant activation of germline dpERK signals. These findings indicate regulatory mechanisms of stem cell niche homeostasis in the Drosophila testis." @default.
• W3149619011 created "2021-04-13" @default.
• W3149619011 creator A5001575535 @default.
• W3149619011 creator A5002339042 @default.
• W3149619011 creator A5006323110 @default.
• W3149619011 creator A5026135474 @default.
• W3149619011 creator A5034845046 @default.
• W3149619011 creator A5036836337 @default.
• W3149619011 creator A5037308715 @default.
• W3149619011 creator A5049792044 @default.
• W3149619011 creator A5056693702 @default.
• W3149619011 creator A5058817050 @default.
• W3149619011 creator A5065418722 @default.
• W3149619011 creator A5079522545 @default.
• W3149619011 creator A5079549927 @default.
• W3149619011 date "2021-04-06" @default.
• W3149619011 modified "2023-10-12" @default.
• W3149619011 title "Somatic CG6015 mediates cyst stem cell maintenance and germline stem cell differentiation via EGFR signaling in Drosophila testes" @default.
• W3149619011 cites W1491598325 @default.
• W3149619011 cites W1645378787 @default.
• W3149619011 cites W1670105114 @default.
• W3149619011 cites W1910221226 @default.
• W3149619011 cites W1964874228 @default.
• W3149619011 cites W1969104713 @default.
• W3149619011 cites W1971463047 @default.
• W3149619011 cites W1972337317 @default.
• W3149619011 cites W1973666272 @default.
• W3149619011 cites W1974754565 @default.
• W3149619011 cites W1997479332 @default.
• W3149619011 cites W2003862179 @default.
• W3149619011 cites W2006975203 @default.
• W3149619011 cites W2013655403 @default.
• W3149619011 cites W2017921050 @default.
• W3149619011 cites W2039942560 @default.
• W3149619011 cites W2045673558 @default.
• W3149619011 cites W2055380229 @default.
• W3149619011 cites W2055986307 @default.
• W3149619011 cites W2056794812 @default.
• W3149619011 cites W2060769929 @default.
• W3149619011 cites W2065256482 @default.
• W3149619011 cites W2066751609 @default.
• W3149619011 cites W2076633253 @default.
• W3149619011 cites W2081707173 @default.
• W3149619011 cites W2086265207 @default.
• W3149619011 cites W2090484897 @default.
• W3149619011 cites W2104031957 @default.
• W3149619011 cites W2120646730 @default.
• W3149619011 cites W2128836076 @default.
• W3149619011 cites W2129429754 @default.
• W3149619011 cites W2152665254 @default.
• W3149619011 cites W2153934067 @default.
• W3149619011 cites W2154004479 @default.
• W3149619011 cites W2261826398 @default.
• W3149619011 cites W2313113799 @default.
• W3149619011 cites W2332799251 @default.
• W3149619011 cites W2416675056 @default.
• W3149619011 cites W2503531540 @default.
• W3149619011 cites W2511716948 @default.
• W3149619011 cites W2588177024 @default.
• W3149619011 cites W2744615483 @default.
• W3149619011 cites W2799510265 @default.
• W3149619011 cites W2884887817 @default.
• W3149619011 cites W2894336728 @default.
• W3149619011 cites W2928205820 @default.
• W3149619011 cites W2929377702 @default.
• W3149619011 cites W2952439689 @default.
• W3149619011 cites W2977454722 @default.
• W3149619011 cites W2999234376 @default.
• W3149619011 doi "https://doi.org/10.1038/s41420-021-00452-w" @default.
• W3149619011 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8024382" @default.
• W3149619011 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33824283" @default.
• W3149619011 hasPublicationYear "2021" @default.
• W3149619011 type Work @default.
• W3149619011 sameAs 3149619011 @default.
• W3149619011 citedByCount "5" @default.
• W3149619011 countsByYear W31496190112022 @default.
• W3149619011 countsByYear W31496190112023 @default.
• W3149619011 crossrefType "journal-article" @default.
• W3149619011 hasAuthorship W3149619011A5001575535 @default.
• W3149619011 hasAuthorship W3149619011A5002339042 @default.
• W3149619011 hasAuthorship W3149619011A5006323110 @default.
• W3149619011 hasAuthorship W3149619011A5026135474 @default.
• W3149619011 hasAuthorship W3149619011A5034845046 @default.
• W3149619011 hasAuthorship W3149619011A5036836337 @default.
• W3149619011 hasAuthorship W3149619011A5037308715 @default.
• W3149619011 hasAuthorship W3149619011A5049792044 @default.
• W3149619011 hasAuthorship W3149619011A5056693702 @default.
• W3149619011 hasAuthorship W3149619011A5058817050 @default.
• W3149619011 hasAuthorship W3149619011A5065418722 @default.
• W3149619011 hasAuthorship W3149619011A5079522545 @default.
• W3149619011 hasAuthorship W3149619011A5079549927 @default.
• W3149619011 hasBestOaLocation W31496190111 @default.
• W3149619011 hasConcept C104317684 @default.
• W3149619011 hasConcept C109825262 @default.
• W3149619011 hasConcept C134305767 @default.
• W3149619011 hasConcept C148738053 @default.
• W3149619011 hasConcept C173396325 @default.
• W3149619011 hasConcept C20875687 @default.
• W3149619011 hasConcept C2776041557 @default.
• W3149619011 hasConcept C2779122487 @default.

• next