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- W3149643148 abstract "Objective To study the effects of 50 Hz power frequency magnetic fields on signal transduction pathway of P38 mitogen activated protein kinase(P38 MAPK),and explore the cellular signal transduction mechanism of the biological effects induced by power frequency magnetic fields. Methods Chinese hamster lung(CHL) cell line was exposed to power frequency magnetic fields with two intensities(0.1 and 0.4 mT) for different exposure durations.The cytoplasmic protein was extracted.The phosphorylated(activated) and non phosphorylated P38 MAPK and MKK3/MKK6 were measured by Western blotting analysis with their specific corresponding antibodies. Results Power frequency magnetic fields at 0.4 mT for 10 min could transitorily induce the activation of P38 MAPK and after 15 min the phosphorylation of P38 MAPK restored to control level,while 0.1 mT power frequency magnetic fields could not induce the activation of P38 MAPK within 24 h.However,both 0.1 mT and 0.4 mT power frequency magnetic fields could not phosphorylate(activate) the MKK3/MKK6,which is a general upstream kinase of P38 MAPK. Conclusion Power frequency magnetic fields could transitorily activate the P38 MAPK,but not MKK3/MKK6.The activation mechanism of P38 MAPK needs to be further identified." @default.
- W3149643148 created "2021-04-13" @default.
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- W3149643148 date "2002-01-01" @default.
- W3149643148 modified "2023-09-23" @default.
- W3149643148 title "Exposure to power-frequency magnetic fields can induce activation of P38 mitogen-activated protein kinase" @default.
- W3149643148 hasPublicationYear "2002" @default.
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