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- W3149661063 abstract "In oligotrophic oceans, low bioavailability of Fe is a key factor limiting primary productivity. However, excessive Fe in cells leads to the Fenton reaction, which is toxic to cells. Cyanobacteria must strictly maintain intracellular Fe homeostasis. Here, we knocked out a series of genes encoding efflux systems in Synechocystis sp. PCC 6803, and found eight genes that are required for high Fe detoxification. Unexpectedly, the HlyBD-TolC efflux system plays an important role in the adaptation of Synechocystis under Fe-deficient conditions. Mutants of HlyD and TolC grew worse than the wild-type strain under low-Fe conditions and showed significantly lower intracellular Fe contents than the wild-type strain. We excluded the possibility that the low Fe sensitivity of the HlyBD-TolC mutants was caused by a loss of the S-layer, the main extracellular protein secreted via this efflux system. Inactivation of the HlyD protein influenced type IV pili formation and direct inactivation of type IV pili related genes affected the adaptation to low-Fe conditions. HlyBD-TolC system is likely involved in the formation of type IV pili and indirectly influenced Fe acquisition. Our findings suggest that efflux system in non-siderophore-producing cyanobacteria can facilitate Fe uptake and help cells adapt to Fe-deficient conditions via novel pathways." @default.
- W3149661063 created "2021-04-13" @default.
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- W3149661063 date "2021-04-26" @default.
- W3149661063 modified "2023-10-16" @default.
- W3149661063 title "Special roles for efflux systems in iron homeostasis of non‐siderophore‐producing cyanobacteria" @default.
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- W3149661063 doi "https://doi.org/10.1111/1462-2920.15506" @default.
- W3149661063 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33817959" @default.
- W3149661063 hasPublicationYear "2021" @default.
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