FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3149669148> ?p ?o ?g. }

• W3149669148 endingPage "1619" @default.
• W3149669148 startingPage "1598" @default.
• W3149669148 abstract "Cigarette smoking is one major modifiable risk factor in the development and progression of chronic obstructive pulmonary disease and cardiovascular disease. To characterize and compare cigarette smoke (CS)-induced disease endpoints after exposure in either whole-body (WB) or nose-only (NO) exposure systems, we exposed apolipoprotein E-deficient mice to filtered air (Sham) or to the same total particulate matter (TPM) concentration of mainstream smoke from 3R4F reference cigarettes in NO or WB exposure chambers (EC) for 2 months. At matching TPM concentrations, we observed similar concentrations of carbon monoxide, acetaldehyde, and acrolein, but higher concentrations of nicotine and formaldehyde in NOEC than in WBEC. In both exposure systems, CS exposure led to the expected adaptive changes in nasal epithelia, altered lung function, lung inflammation, and pronounced changes in the nasal epithelial transcriptome and lung proteome. Exposure in the NOEC caused generally more severe histopathological changes in the nasal epithelia and a higher stress response as indicated by body weight decrease and lower blood lymphocyte counts compared with WB exposed mice. Erythropoiesis, and increases in total plasma triglyceride levels and atherosclerotic plaque area were observed only in CS-exposed mice in the WBEC group but not in the NOEC group. Although the composition of CS in the breathing zone is not completely comparable in the two exposure systems, the CS-induced respiratory disease endpoints were largely confirmed in both systems, with a higher magnitude of severity after NO exposure. CS-accelerated atherosclerosis and other pro-atherosclerotic factors were only significant in WBEC." @default.
• W3149669148 created "2021-04-13" @default.
• W3149669148 creator A5008160276 @default.
• W3149669148 creator A5012278670 @default.
• W3149669148 creator A5017919384 @default.
• W3149669148 creator A5021007589 @default.
• W3149669148 creator A5032018257 @default.
• W3149669148 creator A5044975842 @default.
• W3149669148 creator A5045738264 @default.
• W3149669148 creator A5046219213 @default.
• W3149669148 creator A5047111847 @default.
• W3149669148 creator A5056000409 @default.
• W3149669148 creator A5066115942 @default.
• W3149669148 creator A5070083220 @default.
• W3149669148 creator A5075203903 @default.
• W3149669148 creator A5079510778 @default.
• W3149669148 creator A5087038430 @default.
• W3149669148 creator A5088310438 @default.
• W3149669148 creator A5091278690 @default.
• W3149669148 date "2021-04-06" @default.
• W3149669148 modified "2023-10-04" @default.
• W3149669148 title "Impact of whole‐body versus nose‐only inhalation exposure systems on systemic, respiratory, and cardiovascular endpoints in a 2‐month cigarette smoke exposure study in the ApoE ^−/− mouse model" @default.
• W3149669148 cites W1118098720 @default.
• W3149669148 cites W1613434511 @default.
• W3149669148 cites W1825307153 @default.
• W3149669148 cites W1890979445 @default.
• W3149669148 cites W1967454801 @default.
• W3149669148 cites W1968069972 @default.
• W3149669148 cites W1969832276 @default.
• W3149669148 cites W1974240937 @default.
• W3149669148 cites W1976029010 @default.
• W3149669148 cites W1976359031 @default.
• W3149669148 cites W1979778692 @default.
• W3149669148 cites W1987148365 @default.
• W3149669148 cites W1988964726 @default.
• W3149669148 cites W1994055361 @default.
• W3149669148 cites W1997707189 @default.
• W3149669148 cites W2005185930 @default.
• W3149669148 cites W2007486636 @default.
• W3149669148 cites W2009487673 @default.
• W3149669148 cites W2010457001 @default.
• W3149669148 cites W2018412362 @default.
• W3149669148 cites W2018984280 @default.
• W3149669148 cites W2023010129 @default.
• W3149669148 cites W2024904679 @default.
• W3149669148 cites W2025485837 @default.
• W3149669148 cites W2030476152 @default.
• W3149669148 cites W2033035351 @default.
• W3149669148 cites W2034642652 @default.
• W3149669148 cites W2036558965 @default.
• W3149669148 cites W2040652437 @default.
• W3149669148 cites W2049009575 @default.
• W3149669148 cites W2059061504 @default.
• W3149669148 cites W2059887272 @default.
• W3149669148 cites W2063473876 @default.
• W3149669148 cites W2067952794 @default.
• W3149669148 cites W2085530326 @default.
• W3149669148 cites W2089250591 @default.
• W3149669148 cites W2090836206 @default.
• W3149669148 cites W2095627078 @default.
• W3149669148 cites W2095900642 @default.
• W3149669148 cites W2104716397 @default.
• W3149669148 cites W2112220625 @default.
• W3149669148 cites W2113475163 @default.
• W3149669148 cites W2113878188 @default.
• W3149669148 cites W2116670791 @default.
• W3149669148 cites W2116889297 @default.
• W3149669148 cites W2120890012 @default.
• W3149669148 cites W2122598723 @default.
• W3149669148 cites W2125709882 @default.
• W3149669148 cites W2127082223 @default.
• W3149669148 cites W2127168600 @default.
• W3149669148 cites W2135827569 @default.
• W3149669148 cites W2140764802 @default.
• W3149669148 cites W2143059939 @default.
• W3149669148 cites W2143724908 @default.
• W3149669148 cites W2145025818 @default.
• W3149669148 cites W2159545009 @default.
• W3149669148 cites W2159981521 @default.
• W3149669148 cites W2160697532 @default.
• W3149669148 cites W2162143298 @default.
• W3149669148 cites W2163411228 @default.
• W3149669148 cites W2167778120 @default.
• W3149669148 cites W2167816339 @default.
• W3149669148 cites W2203362636 @default.
• W3149669148 cites W2254323136 @default.
• W3149669148 cites W2329441354 @default.
• W3149669148 cites W2335424366 @default.
• W3149669148 cites W2395253867 @default.
• W3149669148 cites W2476842411 @default.
• W3149669148 cites W2525750312 @default.
• W3149669148 cites W2546684996 @default.
• W3149669148 cites W2573670608 @default.
• W3149669148 cites W2751173961 @default.
• W3149669148 cites W2768063331 @default.
• W3149669148 cites W2857722519 @default.
• W3149669148 cites W2911337652 @default.
• W3149669148 cites W2921073672 @default.

• next