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• W3149671145 abstract "Neurodevelopmental and neurodegenerative diseases (NDDs) with severe neurological/psychiatric symptoms, such as cerebrovascular pathology in AD, CAA, and chronic stroke, have brought greater attention with their incidence and prevalence having markedly increased over the past few years. Causes of the significant neuropathologies, especially those observed in neurological diseases in the CNS, are commonly believed to involve multiple factors such as an age, a total environment, genetics, and an immunity contributing to their progression, neuronal, and vascular injuries. We primarily focused on the studies of glial involvement/dysfunction in part with the blood-brain barrier (BBB) and the neurovascular unit (NVU) changes, and the vascular mechanisms, which have been both suggested as critical roles in chronic stroke and many other NDDs. It has been noted that glial cells including astrocytes (which outnumber other cell types in the CNS) essentially contribute more to the BBB integrity, extracellular homeostasis, neurotransmitter release, regulation of neurogenic niches in response to neuroinflammatory stimulus, and synaptic plasticity. In a recent study for NDDs utilizing cellular and molecular biology and genetic and pharmacological tools, the role of reactive astrocytes (RACs) and gliosis was demonstrated, able to trigger pathophysiological/psychopathological detrimental changes during the disease progression. We speculate, in particular, the BBB, the NVU, and changes of the astrocytes (potentially different populations from the RACs) not only interfere with neuronal development and synaptogenesis, but also generate oxidative damages, contribute to beta-amyloid clearances and disrupted vasculature, as well as lead to neuroinflammatory disorders. During the past several decades, stem cell therapy has been investigated with a research focus to target related neuro-/vascular pathologies (cell replacement and repair) and neurological/psychiatric symptoms (paracrine protection and homeostasis). Evidence shows that transplantation of neurogenic or vasculogenic cells could be achieved to pursue differentiation and maturation within the diseased brains as expected. It would be hoped that, via regulating functions of astrocytes, astrocytic involvement, and modulation of the BBB, the NVU and astrocytes should be among major targets for therapeutics against NDDs pathogenesis by drug and cell-based therapies. The non-invasive strategies in combination with stem cell transplantation such as the well-tested intranasal deliveries for drug and stem cells by our and many other groups show great translational potentials in NDDs. Neuroimaging and clinically relevant analyzing tools need to be evaluated in various NDDs brains." @default.
• W3149671145 created "2021-04-13" @default.
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• W3149671145 date "2021-03-26" @default.
• W3149671145 modified "2023-10-15" @default.
• W3149671145 title "Glial Cell-Based Vascular Mechanisms and Transplantation Therapies in Brain Vessel and Neurodegenerative Diseases" @default.
• W3149671145 cites W1510588853 @default.
• W3149671145 cites W1550986239 @default.
• W3149671145 cites W1559124240 @default.
• W3149671145 cites W1578613579 @default.
• W3149671145 cites W1599415631 @default.
• W3149671145 cites W1740101348 @default.
• W3149671145 cites W1836457398 @default.
• W3149671145 cites W1836539731 @default.
• W3149671145 cites W1970488832 @default.
• W3149671145 cites W1970916286 @default.
• W3149671145 cites W1974457187 @default.
• W3149671145 cites W1981526622 @default.
• W3149671145 cites W1982527850 @default.
• W3149671145 cites W1992074285 @default.
• W3149671145 cites W1992866322 @default.
• W3149671145 cites W2003475014 @default.
• W3149671145 cites W2005547406 @default.
• W3149671145 cites W2024740970 @default.
• W3149671145 cites W2030131397 @default.
• W3149671145 cites W2031399191 @default.
• W3149671145 cites W2031665749 @default.
• W3149671145 cites W2042622236 @default.
• W3149671145 cites W2042663107 @default.
• W3149671145 cites W204998232 @default.
• W3149671145 cites W2051470818 @default.
• W3149671145 cites W2052889947 @default.
• W3149671145 cites W2059681878 @default.
• W3149671145 cites W2065349788 @default.
• W3149671145 cites W2065520371 @default.
• W3149671145 cites W2065895116 @default.
• W3149671145 cites W2069590633 @default.
• W3149671145 cites W2073472013 @default.
• W3149671145 cites W2074036818 @default.
• W3149671145 cites W2088002295 @default.
• W3149671145 cites W2098723224 @default.
• W3149671145 cites W2098902167 @default.
• W3149671145 cites W2109290881 @default.
• W3149671145 cites W2110020828 @default.
• W3149671145 cites W2110925521 @default.
• W3149671145 cites W2111417854 @default.
• W3149671145 cites W2111523164 @default.
• W3149671145 cites W2117407594 @default.
• W3149671145 cites W2119851178 @default.
• W3149671145 cites W2121396070 @default.
• W3149671145 cites W2122873209 @default.
• W3149671145 cites W2128307173 @default.
• W3149671145 cites W2136515772 @default.
• W3149671145 cites W2139383758 @default.
• W3149671145 cites W2141263950 @default.
• W3149671145 cites W2142639362 @default.
• W3149671145 cites W2144750363 @default.
• W3149671145 cites W2151634337 @default.
• W3149671145 cites W2151643816 @default.
• W3149671145 cites W2156734942 @default.
• W3149671145 cites W2158009878 @default.
• W3149671145 cites W2163917074 @default.
• W3149671145 cites W2169078693 @default.
• W3149671145 cites W2169878140 @default.
• W3149671145 cites W2171320080 @default.
• W3149671145 cites W2318175751 @default.
• W3149671145 cites W2321166975 @default.
• W3149671145 cites W2342120657 @default.
• W3149671145 cites W2399776559 @default.
• W3149671145 cites W2410902285 @default.
• W3149671145 cites W2414352146 @default.
• W3149671145 cites W2444444148 @default.
• W3149671145 cites W2487534313 @default.
• W3149671145 cites W2519107741 @default.
• W3149671145 cites W2521218685 @default.
• W3149671145 cites W2523882335 @default.
• W3149671145 cites W2536398251 @default.
• W3149671145 cites W2554656236 @default.
• W3149671145 cites W2559337830 @default.
• W3149671145 cites W2572173857 @default.
• W3149671145 cites W2582407848 @default.
• W3149671145 cites W2588628451 @default.
• W3149671145 cites W2594462692 @default.
• W3149671145 cites W2595085614 @default.
• W3149671145 cites W2606975747 @default.
• W3149671145 cites W2614764552 @default.
• W3149671145 cites W2616216465 @default.
• W3149671145 cites W2616955232 @default.

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