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• W3149675135 abstract "Gold nanoparticles (AuNPs) represent very attractive and promising drug delivery carriers due to their unique dimensions, adjustable surface functions, and controllable drug release. Therefore, AuNPs are used to overcome the limitations of conventional chemotherapy, for example methotrexate (Mex), one of the first-generation chemotherapy drugs for cancer treatment, whose usefulness has been restricted due to drug resistance and dose-dependent side effects. In the present study, the AuNPs drug delivery system was synthesized and loaded with technetium-99 m radiolabeled Methotrexate (99mTc-Mex) to produce new potential nanoradiopharmaceutical for tumor targeting and further imaging. The Methotrexate loaded gold nanoparticles (Mex-AuNPs) successfully prepared in small spherical particle size (20.3 nm), polydispersity index PDI (< 0.5) and a zeta potential (−17.6 mV) with loading efficiency% (93 ± 1.2%) of methotrexate at 30 min as an optimum stirring time and showed strong absorption peak for Mex-AuNPs at λmax, 525 nm. The in vitro release profile of Mex-AuNPs showed high release percent of methotrexate at pH 5; the Q0.5 h and Q8h were 21.2 ± 1.5% and 92.9 ± 3.4%, respectively. The in vitro cytotoxicity was investigated at different concentrations (0.024–50 μl/100 μl) of Mex-AuNPs (1 mg/ml) against MCF-7 (Michigan Cancer Foundation-7) breast cancer cells by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) assay technique. Mex-AuNPs showed higher anticancer activity with low inhibitory concentration (IC50 = 0.098 μl/100 μl) that was three times lower than the inhibitory concentration (IC50) of methotrexate (IC50 = 0.3 μl/100 μl). 99mTc-Mex complex prepared by direct reduction method at maximum radiochemical yield (RCY)% ̴ 98.3 ± 1.09 % was loaded in AuNPs to form 99mTc-Mex-AuNPs with loading efficiency% (93 ± 1.2 %) at 30 min of stirring time. 99mTc-Mex-AuNPs showed convenient in vitro stability in mice serum up to 24 h with RCY% > 90 %. The preclinical biodistribution studies of 99mTc-Mex-AuNPs were performed in 3 experimental groups A (intravenous (I.V.) injected normal mice), B and C (I.V. and intratumor (I.T.) injected tumor bearing mice, respectively). The 99mTc-Mex-AuNPs achieved highest tumor uptake (93 ± 0.39 %ID/g) and highest Target/NonTarget (T/NT) ratio (58.1 ± 0.91) with high Tumor/Blood (T/B) ratio (25.8 ± 0.11) at 10 min post I.T. injection and retained high tumor uptake (79 ± 0.65 %ID/g) up to 60 min post I.T. injection before escaping into blood stream. Consequently, 99mTc-Mex-AuNPs can be considered as new potential nanoradiopharmaceutical in tumor diagnosis." @default.
• W3149675135 created "2021-04-13" @default.
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• W3149675135 date "2021-08-01" @default.
• W3149675135 modified "2023-10-10" @default.
• W3149675135 title "Amelioration of Tumor Targeting and In Vivo Biodistribution of 99mTc-Methotrexate-Gold Nanoparticles (99mTc-Mex-AuNPs)" @default.
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• W3149675135 cites W1965097716 @default.
• W3149675135 cites W1972106197 @default.
• W3149675135 cites W1973078202 @default.
• W3149675135 cites W1985858988 @default.
• W3149675135 cites W1990164841 @default.
• W3149675135 cites W2002617950 @default.
• W3149675135 cites W2018107585 @default.
• W3149675135 cites W2024510872 @default.
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• W3149675135 cites W2032433624 @default.
• W3149675135 cites W2057141276 @default.
• W3149675135 cites W2063626452 @default.
• W3149675135 cites W2067790699 @default.
• W3149675135 cites W2070263056 @default.
• W3149675135 cites W2085712119 @default.
• W3149675135 cites W2101312385 @default.
• W3149675135 cites W2103351739 @default.
• W3149675135 cites W2109227996 @default.
• W3149675135 cites W2112165279 @default.
• W3149675135 cites W2115029038 @default.
• W3149675135 cites W2116118767 @default.
• W3149675135 cites W2122359359 @default.
• W3149675135 cites W2124953450 @default.
• W3149675135 cites W2133337254 @default.
• W3149675135 cites W2148812205 @default.
• W3149675135 cites W2155128361 @default.
• W3149675135 cites W2157770632 @default.
• W3149675135 cites W2323418370 @default.
• W3149675135 cites W2329345175 @default.
• W3149675135 cites W2332814906 @default.
• W3149675135 cites W2345336015 @default.
• W3149675135 cites W2395012354 @default.
• W3149675135 cites W2555686952 @default.
• W3149675135 cites W2612960828 @default.
• W3149675135 cites W2744748675 @default.
• W3149675135 cites W2750381355 @default.
• W3149675135 cites W2762341360 @default.
• W3149675135 cites W2768257805 @default.
• W3149675135 cites W2771603006 @default.
• W3149675135 cites W2773035170 @default.
• W3149675135 cites W2784049627 @default.
• W3149675135 cites W2792362659 @default.
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• W3149675135 doi "https://doi.org/10.1016/j.xphs.2021.03.021" @default.
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