Matches in SemOpenAlex for { <https://semopenalex.org/work/W3149693229> ?p ?o ?g. }
- W3149693229 abstract "Abstract Nucleolin (NCL, C23) is a multifunctional phosphoprotein that plays a vital role in modulating the survival, proliferation and apoptosis of cancer cells. However, the effects of NCL on cervical cancer and the underlying mechanisms behind this are poorly understood. In the study presented here, Hela cells were transfected with shRNAs targeting the endogenous NCL gene (sh-NCL-Hela). NCL knockdown inhibited cell proliferation and promoted apoptosis both in vivo and in vitro . Mechanistic studies revealed that NCL knockdown inhibited the PI3K/AKT pathway by upregulating FGF, ITGA, TNXB, VEGF, Caspase 3, and Bax, as well as by downregulating AKT, GNB4, CDK6, IL6R, LAMA, PDGFD, PPP2RSA and BCL-2. In addition, the expression levels of apoptosis-related genes after using a PI3K inhibitor LY294002 were consistent with shRNA studies, while treatment with a 740Y-P agonist showed the opposite effect. Altogether, this study uncovered that downregulation of NCL may be a novel treatment strategy for cervical cancer." @default.
- W3149693229 created "2021-04-13" @default.
- W3149693229 creator A5002509297 @default.
- W3149693229 creator A5014861998 @default.
- W3149693229 creator A5030208470 @default.
- W3149693229 creator A5032686951 @default.
- W3149693229 creator A5051046606 @default.
- W3149693229 creator A5054725015 @default.
- W3149693229 creator A5059466925 @default.
- W3149693229 creator A5060549116 @default.
- W3149693229 creator A5070248884 @default.
- W3149693229 creator A5079596808 @default.
- W3149693229 creator A5083900776 @default.
- W3149693229 creator A5087765283 @default.
- W3149693229 date "2021-04-02" @default.
- W3149693229 modified "2023-09-27" @default.
- W3149693229 title "Downregulation of NCL attenuates tumor formation and growth in cervical cancer by targeting the PI3K/AKT pathway" @default.
- W3149693229 cites W1531642676 @default.
- W3149693229 cites W1804197362 @default.
- W3149693229 cites W1845459216 @default.
- W3149693229 cites W1976523417 @default.
- W3149693229 cites W1982081677 @default.
- W3149693229 cites W1988226150 @default.
- W3149693229 cites W1990904959 @default.
- W3149693229 cites W1995812689 @default.
- W3149693229 cites W2008779609 @default.
- W3149693229 cites W2011364690 @default.
- W3149693229 cites W2023823249 @default.
- W3149693229 cites W2039483976 @default.
- W3149693229 cites W2043915025 @default.
- W3149693229 cites W2054925679 @default.
- W3149693229 cites W2065961736 @default.
- W3149693229 cites W2150026213 @default.
- W3149693229 cites W2161908938 @default.
- W3149693229 cites W2180648215 @default.
- W3149693229 cites W2295971206 @default.
- W3149693229 cites W2395740875 @default.
- W3149693229 cites W2741838763 @default.
- W3149693229 cites W2749905937 @default.
- W3149693229 cites W2750517504 @default.
- W3149693229 cites W2770278313 @default.
- W3149693229 cites W2806624664 @default.
- W3149693229 cites W2894087925 @default.
- W3149693229 cites W2896098524 @default.
- W3149693229 cites W2943606118 @default.
- W3149693229 cites W2955421884 @default.
- W3149693229 cites W2958232270 @default.
- W3149693229 cites W2991378168 @default.
- W3149693229 cites W3014722886 @default.
- W3149693229 cites W3092619639 @default.
- W3149693229 doi "https://doi.org/10.1101/2021.04.01.438118" @default.
- W3149693229 hasPublicationYear "2021" @default.
- W3149693229 type Work @default.
- W3149693229 sameAs 3149693229 @default.
- W3149693229 citedByCount "0" @default.
- W3149693229 crossrefType "posted-content" @default.
- W3149693229 hasAuthorship W3149693229A5002509297 @default.
- W3149693229 hasAuthorship W3149693229A5014861998 @default.
- W3149693229 hasAuthorship W3149693229A5030208470 @default.
- W3149693229 hasAuthorship W3149693229A5032686951 @default.
- W3149693229 hasAuthorship W3149693229A5051046606 @default.
- W3149693229 hasAuthorship W3149693229A5054725015 @default.
- W3149693229 hasAuthorship W3149693229A5059466925 @default.
- W3149693229 hasAuthorship W3149693229A5060549116 @default.
- W3149693229 hasAuthorship W3149693229A5070248884 @default.
- W3149693229 hasAuthorship W3149693229A5079596808 @default.
- W3149693229 hasAuthorship W3149693229A5083900776 @default.
- W3149693229 hasAuthorship W3149693229A5087765283 @default.
- W3149693229 hasBestOaLocation W31496932291 @default.
- W3149693229 hasConcept C104317684 @default.
- W3149693229 hasConcept C127561419 @default.
- W3149693229 hasConcept C1491633281 @default.
- W3149693229 hasConcept C173396325 @default.
- W3149693229 hasConcept C185592680 @default.
- W3149693229 hasConcept C190283241 @default.
- W3149693229 hasConcept C2777366897 @default.
- W3149693229 hasConcept C502942594 @default.
- W3149693229 hasConcept C55493867 @default.
- W3149693229 hasConcept C62112901 @default.
- W3149693229 hasConcept C75217442 @default.
- W3149693229 hasConcept C86554907 @default.
- W3149693229 hasConcept C86803240 @default.
- W3149693229 hasConcept C95444343 @default.
- W3149693229 hasConceptScore W3149693229C104317684 @default.
- W3149693229 hasConceptScore W3149693229C127561419 @default.
- W3149693229 hasConceptScore W3149693229C1491633281 @default.
- W3149693229 hasConceptScore W3149693229C173396325 @default.
- W3149693229 hasConceptScore W3149693229C185592680 @default.
- W3149693229 hasConceptScore W3149693229C190283241 @default.
- W3149693229 hasConceptScore W3149693229C2777366897 @default.
- W3149693229 hasConceptScore W3149693229C502942594 @default.
- W3149693229 hasConceptScore W3149693229C55493867 @default.
- W3149693229 hasConceptScore W3149693229C62112901 @default.
- W3149693229 hasConceptScore W3149693229C75217442 @default.
- W3149693229 hasConceptScore W3149693229C86554907 @default.
- W3149693229 hasConceptScore W3149693229C86803240 @default.
- W3149693229 hasConceptScore W3149693229C95444343 @default.
- W3149693229 hasLocation W31496932291 @default.
- W3149693229 hasOpenAccess W3149693229 @default.
- W3149693229 hasPrimaryLocation W31496932291 @default.