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• W3149701412 abstract "Transforming growth factor (TGF)-b1 expres- sion is induced upon liver injury, and plays a critical role in hepatic fibrosis. Antibodies against TGF-b 1r epresent a novel approach in the treatment of hepatic fibrosis. However, TGF-b1 is not a suitable antigen due to immunological tolerance. In the current study, we synthesized a multiple antigenic peptide (MAP) vaccine against the dominant B-cell epitope of TGF-b1. The immunogenicity and poten- tial therapeutic effects of this vaccine were examined using a rat model of hepatic fibrosis. Dominant B-cell epitopes of TGF-b1 were identified using bioinformatic program. An MAP vaccine corresponding to the 90-98 amino acid do- main of TGF-b1 and containing four dendritic arms was synthesized using a 9-fluorenylmethoxycarbonyl solid phase method. Hepatic fibrosis which was induced in male Spra- gue-Dawley rats received a high-fat diet and ethanol (1.8 g/ kg). Starting from the third week, rats were exposed to 40 % carbon tetrachloride (CCl4 ;1 50ll/100 g body weight twice weekly, initially 200 ll/100 g) treatment for a duration of 8 weeks. Rats received the MAP vaccine (100 lg) or Fre- und's adjuvant at weeks 1, 3, 5. A group of rats receiving the fibrosis-inducing regimen alone and a group of healthy rats (receiving an olive oil vehicle alone) were included as controls. At the conclusion of the experiment, serum titre of TGF-b1 antibody was measured using ELISA and a standard liver functional test panel was examined. The extent of" @default.
• W3149701412 created "2021-04-13" @default.
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• W3149701412 date "2015-01-01" @default.
• W3149701412 modified "2023-09-27" @default.
• W3149701412 title "A Targeted Multiple Antigenic Peptide Vaccine Augments the Immune Response to Self TGF-b1 and Suppresses Ongoing Hepatic Fibrosis" @default.
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• W3149701412 hasPublicationYear "2015" @default.
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