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- W3149709669 abstract "Objective To explore the mRNA expression of perforin and granzyme B genes activated by cy totoxic T lymphocytes (CTL) for monitoring early acute rejection after tiver transplantation. Methods The mRNA expression of perforin and granzyme B genes in grafts after gold hamster to rat liver transplantation was examined by reverse transcriptase ploymerase chain reactionin. Histological findings were studied comparatively, and isogenic rat liver transplantation was the control.WT5HZResults The mRNA expression of perforin and granzyme B genes began to be upregulated on the day 3 after transplantation, when no histologic evidence of rejection was found.Levels of expression significantly increased after day 4 and persisted through the whole course of rejection.In contrast,the control group showed no expression of mRNA for perforin and granzyme B. Conclusions The determination of mRNA expression of perforin and granzyme B genes are useful to early diagnosis of acute rejection of liver transplantation." @default.
- W3149709669 created "2021-04-13" @default.
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- W3149709669 date "1999-01-01" @default.
- W3149709669 modified "2023-09-25" @default.
- W3149709669 title "The diagnostic value of perforin and granzyme B genes mRNA expression in acute rejection after hamster to rat orthotopic liver transplantation" @default.
- W3149709669 hasPublicationYear "1999" @default.
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