Matches in SemOpenAlex for { <https://semopenalex.org/work/W3149714755> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W3149714755 abstract "Background Chronic otitis media(COM) is a significant clinical problem.Understanding the mechanisms of COM is critical for its control and treatment.However,little is known of the processes leading to COM as a result of lack of animal models of N-ethyl-N-nitrosourea(ENU) induced mutations in otitis media with effusion(OME).Methods Otoscopy and auditory brain response(ABR) evaluation were carried out under sedation in Nmf391nmf/nmf mice of 2,4,6 and 8 months of age.The mice were killed for study of middle and inner ear pathology.Results Tympanic membrane visualization and ABR thresholds in 1-to 8-month-old Nmf391nmf/nmf mice showed spontaneous OME and inner ear diseases in approximately 100% of the animals.The significant elevation of ABR thresholds suggested a sensorineural component in hearing loss in addition to the conductive loss.Middle and inner ear histology showed various degrees of outer hair cells loss and middle ear inflammation in all the mice,but no inflammation cells in the inner ear.The ABR threshold at 32 kHz was significantly elevated.Conclusions This study shows histopathologic changes in the Nmf391nmf/nmf mouse model of COM with effusion that have not been reported in human COM.This ENU induced mutation model of COM will be valuable for the characterization of middle ear inflammation and inner ear disease processes that are induced by middle ear infections.We propose that COM with effusion in this ENU induced mutation model is the cause of the cochlea hair cells damage." @default.
- W3149714755 created "2021-04-13" @default.
- W3149714755 creator A5036790365 @default.
- W3149714755 date "2010-01-01" @default.
- W3149714755 modified "2023-09-27" @default.
- W3149714755 title "A Model of Spontaneous Chronic Otitis Media with Effusion in Mice with ENU Induced Mutations" @default.
- W3149714755 hasPublicationYear "2010" @default.
- W3149714755 type Work @default.
- W3149714755 sameAs 3149714755 @default.
- W3149714755 citedByCount "0" @default.
- W3149714755 crossrefType "journal-article" @default.
- W3149714755 hasAuthorship W3149714755A5036790365 @default.
- W3149714755 hasConcept C105702510 @default.
- W3149714755 hasConcept C141071460 @default.
- W3149714755 hasConcept C142724271 @default.
- W3149714755 hasConcept C163430725 @default.
- W3149714755 hasConcept C203014093 @default.
- W3149714755 hasConcept C2776439223 @default.
- W3149714755 hasConcept C2776914184 @default.
- W3149714755 hasConcept C2777846895 @default.
- W3149714755 hasConcept C2778500370 @default.
- W3149714755 hasConcept C2780130748 @default.
- W3149714755 hasConcept C2780493683 @default.
- W3149714755 hasConcept C2780607864 @default.
- W3149714755 hasConcept C2780757810 @default.
- W3149714755 hasConcept C2781107614 @default.
- W3149714755 hasConcept C548259974 @default.
- W3149714755 hasConcept C71924100 @default.
- W3149714755 hasConceptScore W3149714755C105702510 @default.
- W3149714755 hasConceptScore W3149714755C141071460 @default.
- W3149714755 hasConceptScore W3149714755C142724271 @default.
- W3149714755 hasConceptScore W3149714755C163430725 @default.
- W3149714755 hasConceptScore W3149714755C203014093 @default.
- W3149714755 hasConceptScore W3149714755C2776439223 @default.
- W3149714755 hasConceptScore W3149714755C2776914184 @default.
- W3149714755 hasConceptScore W3149714755C2777846895 @default.
- W3149714755 hasConceptScore W3149714755C2778500370 @default.
- W3149714755 hasConceptScore W3149714755C2780130748 @default.
- W3149714755 hasConceptScore W3149714755C2780493683 @default.
- W3149714755 hasConceptScore W3149714755C2780607864 @default.
- W3149714755 hasConceptScore W3149714755C2780757810 @default.
- W3149714755 hasConceptScore W3149714755C2781107614 @default.
- W3149714755 hasConceptScore W3149714755C548259974 @default.
- W3149714755 hasConceptScore W3149714755C71924100 @default.
- W3149714755 hasLocation W31497147551 @default.
- W3149714755 hasOpenAccess W3149714755 @default.
- W3149714755 hasPrimaryLocation W31497147551 @default.
- W3149714755 hasRelatedWork W116968409 @default.
- W3149714755 hasRelatedWork W1997880784 @default.
- W3149714755 hasRelatedWork W2003725397 @default.
- W3149714755 hasRelatedWork W2021876107 @default.
- W3149714755 hasRelatedWork W2031148620 @default.
- W3149714755 hasRelatedWork W2050192893 @default.
- W3149714755 hasRelatedWork W2053654867 @default.
- W3149714755 hasRelatedWork W2066157053 @default.
- W3149714755 hasRelatedWork W2086507101 @default.
- W3149714755 hasRelatedWork W2104788043 @default.
- W3149714755 hasRelatedWork W2361544733 @default.
- W3149714755 hasRelatedWork W2366724013 @default.
- W3149714755 hasRelatedWork W2369717120 @default.
- W3149714755 hasRelatedWork W2406043942 @default.
- W3149714755 hasRelatedWork W2410257896 @default.
- W3149714755 hasRelatedWork W2412286250 @default.
- W3149714755 hasRelatedWork W2413649200 @default.
- W3149714755 hasRelatedWork W2469545036 @default.
- W3149714755 hasRelatedWork W2625885422 @default.
- W3149714755 hasRelatedWork W2809836683 @default.
- W3149714755 isParatext "false" @default.
- W3149714755 isRetracted "false" @default.
- W3149714755 magId "3149714755" @default.
- W3149714755 workType "article" @default.