Matches in SemOpenAlex for { <https://semopenalex.org/work/W3149728051> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W3149728051 endingPage "717" @default.
- W3149728051 startingPage "713" @default.
- W3149728051 abstract "Objective: To investigate the effect of Tinospora crispa(T. crispa) extract on matrix metalloproteinase 13(MMP-13) expression and cell migration. Methods: The cytotoxicity of T. crispa extract was examined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay on head and neck squamous cell carcinoma(HNSCC) cell lines. The effect on expression of MMP-13 was analysed by RT-PCR and ELISA. The migration was assessed by wound healing assay. Results: MMP-13 m RNA was highly expressed in the metastatic human HNSCC cell lines, HN22 and HSC-3. T. crispa extract at a concentration of 100.0 μg/m L caused about 50% reduction of cell survival. T. crispa extract at a non-toxic concentration of 12.5, 25.0 and 50.0 μg/m L signii cantly suppressed MMP-13 m RNA expression and secreted MMP-13 in both HN22 and HSC-3. The expression of tissue inhibitors of metalloprotease by HSC-3 cells was attenuated by 25.0 and 50.0 μg/m L of T. crispa extract. Addition of the extract to cells in a wound healing assay showed inhibition of cell migration by HN22 cells. Conclusions: These data suggest that T. crispa could be considered as a potential therapeutic drug to prevent metastasis of HNSCC." @default.
- W3149728051 created "2021-04-13" @default.
- W3149728051 creator A5009594048 @default.
- W3149728051 creator A5030416689 @default.
- W3149728051 creator A5037555370 @default.
- W3149728051 creator A5044689789 @default.
- W3149728051 creator A5045618975 @default.
- W3149728051 creator A5046613336 @default.
- W3149728051 creator A5053091491 @default.
- W3149728051 creator A5078502519 @default.
- W3149728051 creator A5087619965 @default.
- W3149728051 creator A5089158048 @default.
- W3149728051 date "2015-01-01" @default.
- W3149728051 modified "2023-09-23" @default.
- W3149728051 title "Tinospora crispa extract inhibits MMP-13 and migration of head and neck squamous cell carcinoma cell lines" @default.
- W3149728051 hasPublicationYear "2015" @default.
- W3149728051 type Work @default.
- W3149728051 sameAs 3149728051 @default.
- W3149728051 citedByCount "0" @default.
- W3149728051 crossrefType "journal-article" @default.
- W3149728051 hasAuthorship W3149728051A5009594048 @default.
- W3149728051 hasAuthorship W3149728051A5030416689 @default.
- W3149728051 hasAuthorship W3149728051A5037555370 @default.
- W3149728051 hasAuthorship W3149728051A5044689789 @default.
- W3149728051 hasAuthorship W3149728051A5045618975 @default.
- W3149728051 hasAuthorship W3149728051A5046613336 @default.
- W3149728051 hasAuthorship W3149728051A5053091491 @default.
- W3149728051 hasAuthorship W3149728051A5078502519 @default.
- W3149728051 hasAuthorship W3149728051A5087619965 @default.
- W3149728051 hasAuthorship W3149728051A5089158048 @default.
- W3149728051 hasConcept C109316439 @default.
- W3149728051 hasConcept C109523444 @default.
- W3149728051 hasConcept C121608353 @default.
- W3149728051 hasConcept C126322002 @default.
- W3149728051 hasConcept C137738243 @default.
- W3149728051 hasConcept C1491633281 @default.
- W3149728051 hasConcept C153911025 @default.
- W3149728051 hasConcept C185592680 @default.
- W3149728051 hasConcept C189165786 @default.
- W3149728051 hasConcept C202751555 @default.
- W3149728051 hasConcept C203014093 @default.
- W3149728051 hasConcept C2776530083 @default.
- W3149728051 hasConcept C2776833033 @default.
- W3149728051 hasConcept C2780269544 @default.
- W3149728051 hasConcept C502942594 @default.
- W3149728051 hasConcept C54355233 @default.
- W3149728051 hasConcept C55493867 @default.
- W3149728051 hasConcept C71924100 @default.
- W3149728051 hasConcept C81885089 @default.
- W3149728051 hasConcept C86803240 @default.
- W3149728051 hasConceptScore W3149728051C109316439 @default.
- W3149728051 hasConceptScore W3149728051C109523444 @default.
- W3149728051 hasConceptScore W3149728051C121608353 @default.
- W3149728051 hasConceptScore W3149728051C126322002 @default.
- W3149728051 hasConceptScore W3149728051C137738243 @default.
- W3149728051 hasConceptScore W3149728051C1491633281 @default.
- W3149728051 hasConceptScore W3149728051C153911025 @default.
- W3149728051 hasConceptScore W3149728051C185592680 @default.
- W3149728051 hasConceptScore W3149728051C189165786 @default.
- W3149728051 hasConceptScore W3149728051C202751555 @default.
- W3149728051 hasConceptScore W3149728051C203014093 @default.
- W3149728051 hasConceptScore W3149728051C2776530083 @default.
- W3149728051 hasConceptScore W3149728051C2776833033 @default.
- W3149728051 hasConceptScore W3149728051C2780269544 @default.
- W3149728051 hasConceptScore W3149728051C502942594 @default.
- W3149728051 hasConceptScore W3149728051C54355233 @default.
- W3149728051 hasConceptScore W3149728051C55493867 @default.
- W3149728051 hasConceptScore W3149728051C71924100 @default.
- W3149728051 hasConceptScore W3149728051C81885089 @default.
- W3149728051 hasConceptScore W3149728051C86803240 @default.
- W3149728051 hasIssue "9" @default.
- W3149728051 hasLocation W31497280511 @default.
- W3149728051 hasOpenAccess W3149728051 @default.
- W3149728051 hasPrimaryLocation W31497280511 @default.
- W3149728051 hasRelatedWork W1092130609 @default.
- W3149728051 hasRelatedWork W1973926184 @default.
- W3149728051 hasRelatedWork W1984461289 @default.
- W3149728051 hasRelatedWork W2060167247 @default.
- W3149728051 hasRelatedWork W2093258731 @default.
- W3149728051 hasRelatedWork W2145357585 @default.
- W3149728051 hasRelatedWork W2147539574 @default.
- W3149728051 hasRelatedWork W2265848498 @default.
- W3149728051 hasRelatedWork W2285443764 @default.
- W3149728051 hasRelatedWork W2332192930 @default.
- W3149728051 hasRelatedWork W2392894267 @default.
- W3149728051 hasRelatedWork W2410791983 @default.
- W3149728051 hasRelatedWork W2590888565 @default.
- W3149728051 hasRelatedWork W2601018617 @default.
- W3149728051 hasRelatedWork W2760500142 @default.
- W3149728051 hasRelatedWork W3035060966 @default.
- W3149728051 hasRelatedWork W3158698414 @default.
- W3149728051 hasRelatedWork W3169753261 @default.
- W3149728051 hasRelatedWork W3182535637 @default.
- W3149728051 hasRelatedWork W1992333183 @default.
- W3149728051 isParatext "false" @default.
- W3149728051 isRetracted "false" @default.
- W3149728051 magId "3149728051" @default.
- W3149728051 workType "article" @default.